The different clinical facets of

SYN1 autism spectrum disorders genotype-phenotype correlation neurodevelopmental disorders reflex epilepsy synapsins

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2022
Historique:
received: 15 08 2022
accepted: 20 10 2022
entrez: 26 12 2022
pubmed: 27 12 2022
medline: 27 12 2022
Statut: epublish

Résumé

Synapsin-I (SYN1) is a presynaptic phosphoprotein crucial for synaptogenesis and synaptic plasticity. Pathogenic

Identifiants

pubmed: 36568968
doi: 10.3389/fcell.2022.1019715
pii: 1019715
pmc: PMC9773998
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1019715

Informations de copyright

Copyright © 2022 Parenti, Leitão, Kuechler, Villard, Goizet, Courdier, Bayat, Rossi, Julia, Bruel, Tran Mau-Them, Nambot, Lehalle, Willems, Lespinasse, Ghoumid, Caumes, Smol, El Chehadeh, Schaefer, Abi-Warde, Keren, Afenjar, Tabet, Levy, Maruani, Aledo-Serrano, Garming, Milleret-Pignot, Chassevent, Koopmans, Verbeek, Person, Belles, Bellus, Salbert, Kaiser, Mazzola, Convers, Perrin, Piton, Wiegand, Accogli, Brancati, Benfenati, Chatron, Lewis-Smith, Thomas, Zara, Striano, Lesca and Depienne.

Déclaration de conflit d'intérêts

Author RP was employed by GeneDx. RT reports Honoraria from Arvelle/Angelini, Bial, Eisai, GW Pharma/Jazz, Sanofi, UCB Pharma and Zogenix, and unrestricted funding support from Arvelle/Angelini and UNEEG. PS has served on a scientific advisory board for the Italian Agency of the Drug (AIFA); has received honoraria from GW pharma, Kolfarma s.r.l., Proveca Pharma Ltd, and Eisai Inc.; and has received research support from the Italian Ministry of Health (Ricerca Corrente 2022) and Fondazione San Paolo. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

BMC Med Genomics. 2021 Jul 9;14(1):182
pubmed: 34243774
J Neurosci. 2004 Dec 15;24(50):11368-80
pubmed: 15601943
Epilepsia. 2015 Jul;56(7):1098-108
pubmed: 26096837
Genet Med. 2015 May;17(5):405-24
pubmed: 25741868
Epilepsy Res. 2012 May;99(3):252-9
pubmed: 22236379
Nucleic Acids Res. 2019 Jan 8;47(D1):D886-D894
pubmed: 30371827
J Med Genet. 2010 Jun;47(6):404-10
pubmed: 20522430
Front Neurosci. 2019 Nov 08;13:1135
pubmed: 31780880
J Cell Sci. 2008 Sep 15;121(Pt 18):3042-51
pubmed: 18713831
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5977-81
pubmed: 392511
Epilepsy Res. 2013 Feb;103(2-3):153-60
pubmed: 22846639
Hum Mol Genet. 2013 Jun 1;22(11):2186-99
pubmed: 23406870
Mol Syst Biol. 2011 Oct 11;7:539
pubmed: 21988835
J Biol Chem. 1998 Jan 16;273(3):1425-9
pubmed: 9430678
Genome Med. 2021 Mar 17;13(1):40
pubmed: 33726816
Neurology. 2021 Aug 10;97(6):e577-e586
pubmed: 34078716
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
Hum Mutat. 2016 Jun;37(6):564-9
pubmed: 26931183
Protein Sci. 2021 Jan;30(1):60-69
pubmed: 32881105
Hum Mol Genet. 2014 Jan 1;23(1):90-103
pubmed: 23956174
Pediatr Neurol. 2017 Dec;77:61-66
pubmed: 29056246
Clin Genet. 2021 Dec;100(6):766-770
pubmed: 34490615
Epilepsia. 2018 Nov;59(11):2162-2163
pubmed: 30390306
J Cell Biol. 1983 May;96(5):1337-54
pubmed: 6404910
Biol Sex Differ. 2015 Dec 30;6:35
pubmed: 26719789
Transl Psychiatry. 2021 Feb 1;11(1):84
pubmed: 33526774
Sci Rep. 2020 Jan 22;10(1):968
pubmed: 31969655
Science. 1989 Sep 29;245(4925):1474-80
pubmed: 2506642
Front Neurol. 2021 Sep 20;12:736977
pubmed: 34616357
PLoS One. 2013 Jun 20;8(6):e67724
pubmed: 23818987
Epilepsia. 2017 Apr;58(4):522-530
pubmed: 28276060
Cell. 2019 Jan 24;176(3):535-548.e24
pubmed: 30661751
Behav Brain Res. 2013 Aug 15;251:65-74
pubmed: 23280234
Epilepsy Behav. 2009 Apr;14(4):582-90
pubmed: 19236947
Prog Neurobiol. 2010 Aug;91(4):313-48
pubmed: 20438797
Hum Mol Genet. 2017 Dec 1;26(23):4699-4714
pubmed: 28973667
Nat Commun. 2018 Dec 10;9(1):5269
pubmed: 30531953
Genome Biol. 2016 Nov 24;17(1):235
pubmed: 27884173
Hum Brain Mapp. 2018 Aug;39(8):3428-3448
pubmed: 29671924
J Cell Sci. 2006 Oct 15;119(Pt 20):4257-68
pubmed: 17038543
J Neurochem. 2021 Apr;157(2):208-228
pubmed: 32738165
Nature. 1995 Jun 8;375(6531):488-93
pubmed: 7777057
Genome Med. 2017 Mar 21;9(1):26
pubmed: 28327206
Nat Neurosci. 2003 Feb;6(2):127-35
pubmed: 12536209
J Neurochem. 1999 Dec;73(6):2266-71
pubmed: 10582583
Lancet Neurol. 2007 Nov;6(11):970-80
pubmed: 17913586
Hum Mutat. 2015 Oct;36(10):928-30
pubmed: 26220891
Neurosci Biobehav Rev. 2021 Nov;130:33-60
pubmed: 34407457
Hum Mol Genet. 2011 Jun 15;20(12):2297-307
pubmed: 21441247
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489
pubmed: 33237286
Pediatr Neurol. 2017 May;70:34-43.e2
pubmed: 28330790
Front Genet. 2021 Mar 05;12:669107
pubmed: 33747056
Genes (Basel). 2020 Jan 02;11(1):
pubmed: 31906484
Cereb Cortex. 2017 Oct 1;27(10):5014-5023
pubmed: 28922833
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W695-9
pubmed: 20439314
Epilepsia. 2014 Apr;55(4):475-82
pubmed: 24730690
J Neurosci. 2002 Jun 1;22(11):4372-80
pubmed: 12040043
J Biol Chem. 1977 Jul 25;252(14):5155-63
pubmed: 194903
Eur J Hum Genet. 2019 Aug;27(8):1197-1214
pubmed: 31019283
Am J Hum Genet. 2019 Dec 5;105(6):1274-1285
pubmed: 31785789
Epilepsia. 2018 May;59(5):1062-1071
pubmed: 29655203
J Med Genet. 2004 Mar;41(3):183-6
pubmed: 14985377
Bioinformatics. 2014 Feb 01;30(3):335-42
pubmed: 24281696

Auteurs

Ilaria Parenti (I)

Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Elsa Leitão (E)

Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Alma Kuechler (A)

Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Laurent Villard (L)

INSERM, MMG, Faculté de Médecine, Aix-Marseille University, Marseille, France.
Département de Génétique Médicale, APHM, Hôpital d'Enfants de La Timone, Marseille, France.

Cyril Goizet (C)

Service de Génétique Médicale, Bordeaux, France.
Centre de Référence Maladies Rares Neurogénétique, Service de Génétique Médicale, Bordeaux, France.
NRGEN Team, INCIA, CNRS UMR 5287, University of Bordeaux, Bordeaux, France.

Cécile Courdier (C)

Service de Génétique Médicale, Bordeaux, France.
Centre de Référence Maladies Rares Neurogénétique, Service de Génétique Médicale, Bordeaux, France.
NRGEN Team, INCIA, CNRS UMR 5287, University of Bordeaux, Bordeaux, France.

Allan Bayat (A)

Institute for Regional Health Services, University of Southern Denmark, Odense, Denmark.
Department of Epilepsy Genetics and Personalized Medicine, Danish Epilepsy Center, Dianalund, Denmark.
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

Alessandra Rossi (A)

Department of Epilepsy Genetics and Personalized Medicine, Danish Epilepsy Center, Dianalund, Denmark.
Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy.

Sophie Julia (S)

Service de Génétique Médicale, Pôle de Biologie, CHU de Toulouse - Hôpital Purpan, Toulouse, France.

Ange-Line Bruel (AL)

Unité Fonctionnelle Innovation en Diagnostic Génomique des Maladies Rares, FHU-TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
UMR1231 GAD, Inserm - Université Bourgogne-Franche Comté, Dijon, France.

Frédéric Tran Mau-Them (F)

Unité Fonctionnelle Innovation en Diagnostic Génomique des Maladies Rares, FHU-TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
UMR1231 GAD, Inserm - Université Bourgogne-Franche Comté, Dijon, France.

Sophie Nambot (S)

UMR1231 GAD, Inserm - Université Bourgogne-Franche Comté, Dijon, France.

Daphné Lehalle (D)

Unité Fonctionnelle Innovation en Diagnostic Génomique des Maladies Rares, FHU-TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
UMR1231 GAD, Inserm - Université Bourgogne-Franche Comté, Dijon, France.

Marjolaine Willems (M)

Department of Medical Genetics, Rare diseases and Personalized Medicine, CHU Montpellier, University of Montpellier, Montpellier, France.
Inserm U1298, INM, CHU Montpellier, University of Montpellier, Montpellier, France.

James Lespinasse (J)

Service de Cytogenetique, Centre Hospitalier de Chambéry, Chambéry, France.

Jamal Ghoumid (J)

Univ. Lille, ULR7364 RADEME, Lille, France.
CHU Lille, Clinique de Génétique, Guy Fontaine, Lille, France.

Roseline Caumes (R)

Univ. Lille, ULR7364 RADEME, Lille, France.
CHU Lille, Clinique de Génétique, Guy Fontaine, Lille, France.

Thomas Smol (T)

Univ. Lille, ULR7364 RADEME, Lille, France.
CHU Lille, Institut de Génétique Médicale, Lille, France.

Salima El Chehadeh (S)

Service de Génétique Médicale, Institut de Génétique Médicale d'Alsace (IGMA), Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France.

Elise Schaefer (E)

Service de Génétique Médicale, Institut de Génétique Médicale d'Alsace (IGMA), Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Strasbourg, France.

Marie-Thérèse Abi-Warde (MT)

Département de NeuroPédiatrie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Boris Keren (B)

APHP, Département de Génétique, UF de Génomique du Développement, Département de Génétique, Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Université, Paris, France.

Alexandra Afenjar (A)

Département de Génétique, Centre de Référence déficiences Intellectuelles de Causes Rares, APHP, Hôpital Armand Trousseau, Sorbonne Université, Paris, France.

Anne-Claude Tabet (AC)

APHP, Département de Génétique, Hôpital Robert-Debré, Paris, France.

Jonathan Levy (J)

APHP, Département de Génétique, Hôpital Robert-Debré, Paris, France.

Anna Maruani (A)

Department of Child and Adolescent Psychiatry, Robert Debré Hospital, APHP, Paris, France.

Ángel Aledo-Serrano (Á)

Epilepsy and Neurogenetics Program, Neurology Department, Ruber Internacional Hospital, Madrid, Spain.

Waltraud Garming (W)

Sozialpädiatrisches Zentrum, Kinder-und Jugendklinik Gelsenkirchen, Gelsenkirchen, Germany.

Clara Milleret-Pignot (C)

Service de Pédiatrie, CH de Mâcon, Mâcon, France.

Anna Chassevent (A)

Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD, United States.

Marije Koopmans (M)

Department of Genetics, Utrecht University Medical Center, Utrecht, Netherlands.

Nienke E Verbeek (NE)

Department of Genetics, Utrecht University Medical Center, Utrecht, Netherlands.

Richard Person (R)

GeneDx, Gaithersburg, MD, United States.

Rebecca Belles (R)

Medical Genetics, Geisinger Medical Center, Danville, PA, United States.

Gary Bellus (G)

Medical Genetics, Geisinger Medical Center, Danville, PA, United States.

Bonnie A Salbert (BA)

Medical Genetics, Geisinger Medical Center, Danville, PA, United States.

Frank J Kaiser (FJ)

Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Essener Zentrum für Seltene Erkrankungen (EZSE), Universitätsklinikum Essen, Essen, Germany.

Laure Mazzola (L)

Department of Neurology, University Hospital, Lyon Neuroscience Research Center (CRNL), INSERM U1028, CNRS UMR5292, Lyon, France.
Department of Neurology, University Hospital, Saint-Etienne, France.

Philippe Convers (P)

Department of Neurology, University Hospital, Lyon Neuroscience Research Center (CRNL), INSERM U1028, CNRS UMR5292, Lyon, France.
Department of Neurology, University Hospital, Saint-Etienne, France.

Laurine Perrin (L)

Department of Paediatric Physical Medicine and Rehabilitation, CHU Saint-Étienne, Hôpital Bellevue, Rhône-Alpes Reference Centre for Neuromuscular Diseases, Saint-Étienne, France.

Amélie Piton (A)

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.
Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France.
Université de Strasbourg, Illkirch, France.

Gert Wiegand (G)

Division of Pediatric Neurology, Department of Pediatrics, Asklepios Klinik Nord-Heidberg, Hamburg, Germany.
Department of Pediatric and Adolescent Medicine II (Neuropediatrics, Social Pediatrics), University Medical Centre Schleswig-Holstein, Kiel, Germany.

Andrea Accogli (A)

Department of Specialized Medicine, Division of Medical Genetics, McGill University Health Centre, Montreal, Qc, Canada.
Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, Qc, Canada.

Francesco Brancati (F)

Department of Life, Human Genetics, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
IRCCS San Raffaele Roma, Rome, Italy.

Fabio Benfenati (F)

Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Geneva, Italy.
IRCCS Ospedale Policlinico San Martino, Geneva, Italy.

Nicolas Chatron (N)

Service de Genetique, Hospices Civils de Lyon, Bron, France.
Institute NeuroMyoGène, Laboratoire Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261 -INSERM U1315, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, France.

David Lewis-Smith (D)

Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Department of Clinical Neurosciences, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.

Rhys H Thomas (RH)

Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Department of Clinical Neurosciences, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom.

Federico Zara (F)

IRCCS G. Gaslini, Genova, Italy.
Department of Neurology, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.

Pasquale Striano (P)

IRCCS G. Gaslini, Genova, Italy.
Department of Neurology, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.

Gaetan Lesca (G)

Service de Genetique, Hospices Civils de Lyon, Bron, France.
Institute NeuroMyoGène, Laboratoire Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261 -INSERM U1315, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, France.

Christel Depienne (C)

Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Classifications MeSH