Decidual macrophages in recurrent spontaneous abortion.

CD11clow/CD11chigh M1/M2 balance decidual macrophages recurrent spontaneous abortion (RSA) the maternal-fetal interface

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 15 07 2022
accepted: 22 11 2022
entrez: 26 12 2022
pubmed: 27 12 2022
medline: 28 12 2022
Statut: epublish

Résumé

Recurrent spontaneous abortion (RSA) is defined as two or more pregnancy loss, affecting the happiness index of fertility couples. The mechanisms involved in the occurrence of RSA are not clear to date. The primary problem for the maternal immune system is how to establish and maintain the immune tolerance to the semi-allogeneic fetuses. During the pregnancy, decidual macrophages mainly play an important role in the immunologic dialogue. The purpose of this study is to explore decidual macrophages, and to understand whether there is a connection between these cells and RSA by analyzing their phenotypes and functions. Pubmed, Web of Science and Embase were searched. The eligibility criterion for this review was evaluating the literature about the pregnancy and macrophages. Any disagreement between the authors was resolved upon discussion and if required by the judgment of the corresponding author. We summarized the latest views on the phenotype, function and dysfunction of decidual macrophages to illuminate its relationship with RSA.

Identifiants

pubmed: 36569856
doi: 10.3389/fimmu.2022.994888
pmc: PMC9781943
doi:

Types de publication

Systematic Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

994888

Informations de copyright

Copyright © 2022 Zhao, Li, Fu, Ren, Jiang and Meng.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Qiu-Yan Zhao (QY)

Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

Qing-Hui Li (QH)

Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

Yao-Yao Fu (YY)

Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

Chun-E Ren (CE)

Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

Ai-Fang Jiang (AF)

Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

Yu-Han Meng (YH)

Center of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

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