The Shank3
ASD model
Shank3
Shank3a
Shank3ΔC
isoform-specific tagging
knock in
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
10
2022
accepted:
23
11
2022
entrez:
26
12
2022
pubmed:
27
12
2022
medline:
27
12
2022
Statut:
epublish
Résumé
Shank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in In this study, we created a novel transgenic mouse line, the Shank3 We show that the endogenous Venus-Shank3a protein is localized in spines and is mainly expressed in the striatum, hippocampus and cortex of the developing and adult brain. We show that Shank3 Altogether, our results show that the Shank3
Sections du résumé
Background
UNASSIGNED
Shank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in
Methods
UNASSIGNED
In this study, we created a novel transgenic mouse line, the Shank3
Results
UNASSIGNED
We show that the endogenous Venus-Shank3a protein is localized in spines and is mainly expressed in the striatum, hippocampus and cortex of the developing and adult brain. We show that Shank3
Conclusion
UNASSIGNED
Altogether, our results show that the Shank3
Identifiants
pubmed: 36570823
doi: 10.3389/fnins.2022.1081010
pmc: PMC9773256
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1081010Informations de copyright
Copyright © 2022 Bouquier, Sakkaki, Raynaud, Hemonnot-Girard, Seube, Compan, Bertaso, Perroy and Moutin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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