The role of adenosine A
A(2A) receptor
Adenosine
Adenosine receptors
Alzheimer's disease
Amyloid
Purinergic signaling
Tau
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
15 03 2023
15 03 2023
Historique:
received:
13
11
2022
revised:
12
12
2022
accepted:
13
12
2022
pubmed:
27
12
2022
medline:
7
2
2023
entrez:
26
12
2022
Statut:
ppublish
Résumé
Adenosine signals through four distinct G protein-coupled receptors that are located at various synapses, cell types and brain areas. Through them, adenosine regulates neuromodulation, neuronal signaling, learning and cognition as well as the sleep-wake cycle, all strongly impacted in neurogenerative disorders, among which Alzheimer's Disease (AD). AD is a complex form of cognitive deficits characterized by two pathological hallmarks: extracellular deposits of aggregated β-amyloid peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. Both lesions contribute to the early dysfunction and loss of synapses which are strongly associated to the development of cognitive decline in AD patients. The present review focuses on the pathophysiological impact of the A
Identifiants
pubmed: 36572177
pii: S0028-3908(22)00438-5
doi: 10.1016/j.neuropharm.2022.109379
pii:
doi:
Substances chimiques
Adenosine
K72T3FS567
tau Proteins
0
Amyloid beta-Peptides
0
Receptor, Adenosine A2A
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109379Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare no conflicts of interest.