Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases.
Inflammation
Inflammatory diseases
Mammalian target of rapamycin
Oxidative stress
Statins
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
03
02
2022
accepted:
12
07
2022
pubmed:
28
12
2022
medline:
3
3
2023
entrez:
27
12
2022
Statut:
ppublish
Résumé
Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries.
Identifiants
pubmed: 36574095
doi: 10.1007/s10787-022-01077-w
pii: 10.1007/s10787-022-01077-w
pmc: PMC9792946
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-75Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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