Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
SARS-CoV-2
copy-number variation
immunoglobulin allelic diversity
neutralizing antibody
single-nucleotide polymorphism
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
10 01 2023
10 01 2023
Historique:
received:
28
05
2022
revised:
23
09
2022
accepted:
07
12
2022
pubmed:
28
12
2022
medline:
14
1
2023
entrez:
27
12
2022
Statut:
ppublish
Résumé
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent health care workers, focusing on the IGHV1-69 gene, which has the highest level of allelic variation of all IGHV genes. The IGHV1-69
Identifiants
pubmed: 36574772
pii: S1074-7613(22)00641-0
doi: 10.1016/j.immuni.2022.12.005
pmc: PMC9742198
pii:
doi:
Substances chimiques
Immunoglobulin Heavy Chains
0
Antibodies, Viral
0
Antibodies, Neutralizing
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-206.e7Subventions
Organisme : Medical Research Council
ID : MR/W005611/1
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests M. Corcoran and G.B.K.H. are founders of ImmuneDiscover Sweden.
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