Imaginal disc growth factor is involved in melanin synthesis and energy metabolism in Bombyx mori.
Bombyx mori
IDGF
energy metabolism
melanin synthesis
transcriptome
Journal
Archives of insect biochemistry and physiology
ISSN: 1520-6327
Titre abrégé: Arch Insect Biochem Physiol
Pays: United States
ID NLM: 8501752
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
revised:
06
12
2022
received:
17
10
2022
accepted:
13
12
2022
pubmed:
29
12
2022
medline:
23
3
2023
entrez:
28
12
2022
Statut:
ppublish
Résumé
The imaginal disc growth factor (IDGF), belonging to the glycoside hydrolase 18 family, plays an important role in various physiological processes in insects. However, the detail physiological function of IDGF is still unclear. In this study, transcriptome analysis was performed on the fatbody isolated from staged control and BmIDGF mutant silkworm larvae. Transcriptional profiling revealed that the absence of BmIDGF significantly affected differentially expressed genes involved in tyrosine and purine metabolism, as well as multiple energy metabolism pathways, including glycolysis, galactose, starch, and sucrose metabolism. The interruption of BmIDGF caused similar and specific gene expression changes to male and female fatbody. Furthermore, a genome-scale metabolic network integrating metabolomic and transcriptomic datasets revealed 11 pathways significantly altered at the transcriptional and metabolic levels, including amino acid, carbohydrate, uric acid metabolism pathways, insect hormone biosynthesis, and ABC transporters. In conclusion, this multiomics analysis suggests that IDGF is involved in gene-metabolism interactions, revealing its unique role in melanin synthesis and energy metabolism. This study provides new insights into the physiological function of IDGF in insects.
Substances chimiques
Melanins
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21995Subventions
Organisme : Natural Science Foundation of Zhejiang Province
ID : LR22C040001
Organisme : National Natural Science Foundation of China
ID : 32170483
Organisme : National Natural Science Foundation of China
ID : 31970460
Organisme : Zhejiang Provincial Key Laboratory Construction Plans
ID : 2020E10025
Informations de copyright
© 2022 Wiley Periodicals LLC.
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