Selection of Knees With Subsequent Cartilage Thickness Loss Based on Magnetic Resonance Imaging Semiquantitative Grading: Data From the Osteoarthritis Initiative Foundation for the National Institutes of Health Biomarker Cohort.
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
18
11
2022
received:
19
07
2022
accepted:
20
12
2022
medline:
28
7
2023
pubmed:
29
12
2022
entrez:
28
12
2022
Statut:
ppublish
Résumé
To investigate which magnetic resonance imaging (MRI)-based articular pathologies are predictive of subsequent medial femorotibial compartment quantitative cartilage thickness loss and therefore suitable for enrichment of clinical trials with participants showing a high likelihood for structural progression. Semiquantitative MRI Osteoarthritis Knee Score (MOAKS) assessments at baseline and quantitative cartilage thickness measurements at baseline and year-2 follow-up were performed in 599 participants (age 62 years; body mass index 31 kg/m Presence of MFTC MOAKS cartilage damage (odds ratio [OR] 2.77 [95% confidence interval (95% CI) 1.76, 4.36]), MFTC bone marrow lesions (OR 2.69 [95% CI 1.89, 3.83]), medial meniscus extrusion or damage (OR 2.21 [95% CI 1.37, 3.55]), as well as MOAKS severity subscales for cartilage and meniscus damage were associated with subsequent progression. The SRM was greater in knees with than in knees without the presence of these pathologies and was associated with the severity of those pathologies. MRI-based grading of articular pathologies makes it possible to specifically select progressor knees suitable for inclusion in clinical trials but also to identify knees in which treatment is not indicated (e.g., knees without cartilage damage despite presence of radiographic osteoarthritis).
Substances chimiques
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT00080171']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1773-1782Subventions
Organisme : NHLBI NIH HHS
ID : HHSN2682010000
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01-AR-2-2258
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01-AR-2-2259
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01-AR-2-2260
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01-AR-2-2261
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01-AR-2-2262
Pays : United States
Informations de copyright
© 2022 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
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