Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management.
Cardiovascular risk
Liver transplantation
Metabolic syndrome
NAFLD
NASH
Journal
Clinical and molecular hepatology
ISSN: 2287-285X
Titre abrégé: Clin Mol Hepatol
Pays: Korea (South)
ID NLM: 101586730
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
10
11
2022
accepted:
22
12
2022
pubmed:
29
12
2022
medline:
16
3
2023
entrez:
28
12
2022
Statut:
ppublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) is currently the fastest growing indication to liver transplantation (LT) in Western Countries, both for end stage liver disease and hepatocellular carcinoma. NAFLD/non-alcoholic steatohepatitis (NASH) is often expression of a systemic metabolic syndrome; therefore, NAFLD/NASH patients require a multidisciplinary approach for a proper pre-surgical evaluation, which is important to achieve a post-transplant outcome comparable to that of other indications to LT. NAFLD/NASH patients are also at higher risk of post-transplant cardiovascular events, diabetes, dyslipidemia, obesity, renal impairment and recurrent NASH. Lifestyle modifications, included diet and physical activity, are key to improve survival and quality of life after transplantation. A tailored immunosuppressive regimen may be proposed in selected patients. Development of new drugs for the treatment of recurrent NASH is awaited.
Identifiants
pubmed: 36577425
pii: cmh.2022.0392
doi: 10.3350/cmh.2022.0392
pmc: PMC10029965
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S286-S301Commentaires et corrections
Type : CommentIn
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