Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats.
BDNF
Choline supplementation
Gene expression
Hypothyroidism
Rat
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
03
08
2022
accepted:
06
10
2022
pubmed:
29
12
2022
medline:
16
3
2023
entrez:
28
12
2022
Statut:
ppublish
Résumé
Thyroid hormones play a vital function in the maturation in the course of mind development. Regarding the well-known effects of choline on brain-derived neurotrophic factor (BDNF), the study examined the effects of choline on hippocampal BDNF gene expression in maternal hypothyroidism rats. To induce the hypothyroidism, 6-propyl-2-thiouracil was introduced to the ingesting water from the sixth day of gestation to twenty-first postnatal day (PND). Choline-treatment started twice a day on the first day of gestation until PND 21. On PND28, pups were sacrificed. The expression of BDNF gene was evaluated after the hippocampus was harvested. Our results demonstrated that both male and female pre-pubertal offspring rats' BDNF gene expression was decreased by developmental hypothyroidism. Choline increases the ratio of relative gene expression of BDNF in the hippocampus of males and females in the control/hypothyroidism group, especially in males. It can be concluded that maternal choline supplementation on the first day of gestation until PND 21 improves brain development and cognitive function in pre-pubertal offspring rats regarding control/hypothyroidism groups.
Sections du résumé
BACKGROUND
BACKGROUND
Thyroid hormones play a vital function in the maturation in the course of mind development. Regarding the well-known effects of choline on brain-derived neurotrophic factor (BDNF), the study examined the effects of choline on hippocampal BDNF gene expression in maternal hypothyroidism rats.
METHODS AND RESULTS
RESULTS
To induce the hypothyroidism, 6-propyl-2-thiouracil was introduced to the ingesting water from the sixth day of gestation to twenty-first postnatal day (PND). Choline-treatment started twice a day on the first day of gestation until PND 21. On PND28, pups were sacrificed. The expression of BDNF gene was evaluated after the hippocampus was harvested. Our results demonstrated that both male and female pre-pubertal offspring rats' BDNF gene expression was decreased by developmental hypothyroidism. Choline increases the ratio of relative gene expression of BDNF in the hippocampus of males and females in the control/hypothyroidism group, especially in males.
CONCLUSIONS
CONCLUSIONS
It can be concluded that maternal choline supplementation on the first day of gestation until PND 21 improves brain development and cognitive function in pre-pubertal offspring rats regarding control/hypothyroidism groups.
Identifiants
pubmed: 36577834
doi: 10.1007/s11033-022-08014-8
pii: 10.1007/s11033-022-08014-8
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Choline
N91BDP6H0X
Bdnf protein, rat
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2351-2356Subventions
Organisme : Urmia University of Medical Sciences
ID : 449
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Chiovato L, Magri F, Carlé A (2019) Hypothyroidism in context: where we’ve been and where we’re going. Adv Ther 36(Suppl 2):47–58
doi: 10.1007/s12325-019-01080-8
pubmed: 31485975
pmcid: 6822815
Turkal R, Turan CA, Elbasan O et al (2022) Accurate interpretation of thyroid dysfunction during pregnancy: should we continue to use published guidelines instead of population-based gestation-specific reference intervals for the thyroid-stimulating hormone (TSH)? BMC Pregnancy Childbirth 22:271
doi: 10.1186/s12884-022-04608-z
pubmed: 35361138
pmcid: 8973886
Salazar P, Villaseca P, Cisternas P, Inestrosa NC (2021) Neurodevelopmental impact of the offspring by thyroid hormone system-disrupting environmental chemicals during pregnancy. Environ Res 200:111345
doi: 10.1016/j.envres.2021.111345
pubmed: 34087190
Päkkilä F, Männistö T, Hartikainen AL et al (2015) Maternal and child’s thyroid function and child’s intellect and scholastic performance. Thyroid 25(12):1363–1374
doi: 10.1089/thy.2015.0197
pubmed: 26438036
pmcid: 4684651
Anifantaki F, Pervanidou P, Lambrinoudaki I, Panoulis K, Vlahos N, Eleftheriades M (2021) Maternal prenatal stress, thyroid function and neurodevelopment of the offspring: a mini review of the literature. Front Neurosci 15:692446
doi: 10.3389/fnins.2021.692446
pubmed: 34566560
pmcid: 8455916
Cooke GE, Mullally S, Correia N, O’Mara SM, Gibney J (2014) Hippocampal volume is decreased in adults with hypothyroidism. Thyroid 24(3):433–440
doi: 10.1089/thy.2013.0058
pubmed: 24205791
Karin O, Raz M, Tendler A, Bar A, Korem Kohanim Y, Milo T, Alon U (2020) A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks. Mol Syst Biol 16(7):e9510
doi: 10.15252/msb.20209510
pubmed: 32672906
pmcid: 7364861
Walsh K, McCormack CA, Webster R et al (2019) Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes. Proc Natl Acad Sci USA 116(48):23996–24005
doi: 10.1073/pnas.1905890116
pubmed: 31611411
pmcid: 6883837
Ali MA, Nasir M, Pasha TN et al (2020) Preventive therapy of antioxidant vitamins against the blood choline levels in cardiovascular patients. Cell Mol Biol (Noisy-le-grand) 66(4):184–190
doi: 10.14715/cmb/2020.66.4.22
pubmed: 32583779
Ali MA, Nasir M, Pasha TN et al (2020) Association of life style and dietary habits with blood choline and cardiovascular outcome. Cell Mol Biol Biol (Noisy-le-grand) 66(4):178–183
doi: 10.14715/cmb/2020.66.4.21
Brailoiu E, Chakraborty S, Brailoiu GC et al (2019) Choline is an intracellular messenger linking extracellular stimuli to IP
doi: 10.1016/j.celrep.2018.12.051
pubmed: 30625315
pmcid: 6326163
Halder N, Lal G (2021) Cholinergic system and its therapeutic importance in inflammation and autoimmunity. Front Immunol 12:660342
doi: 10.3389/fimmu.2021.660342
pubmed: 33936095
pmcid: 8082108
Derbyshire E, Obeid R (2020) Choline, neurological development and brain function: a systematic review focusing on the first 1000 days. Nutrients 12(6):1731
doi: 10.3390/nu12061731
pubmed: 32531929
pmcid: 7352907
Poly C, Massaro JM, Seshadri S et al (2011) The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr 94(6):1584–1591
doi: 10.3945/ajcn.110.008938
pubmed: 22071706
pmcid: 3252552
Caudill MA, Strupp BJ, Muscalu L, Nevins JEH, Canfield RL (2018) Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. FASEB J 32(4):2172–2180
doi: 10.1096/fj.201700692RR
pubmed: 29217669
pmcid: 6988845
Miranda M, Morici JF, Zanoni MB, Bekinschtein P (2019) Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci 13:363
doi: 10.3389/fncel.2019.00363
pubmed: 31440144
pmcid: 6692714
Rashidy-Pour A, Derafshpour L, Vafaei AA et al (2020) Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats. Behav Pharmacol 31(7):641–651
doi: 10.1097/FBP.0000000000000572
pubmed: 32826427
Cattaneo A, Cattane N, Begni V, Pariante CM, Riva MA (2016) The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders. Transl Psychiatry 6(11):e958
doi: 10.1038/tp.2016.214
pubmed: 27874848
pmcid: 5314126
Urbina-Varela R, Soto-Espinoza MI, Vargas R, Quiñones L, Del Campo A (2020) Influence of BDNF genetic polymorphisms in the pathophysiology of aging-related diseases. Aging Dis 11(6):1513–1526
doi: 10.14336/AD.2020.0310
pubmed: 33269104
pmcid: 7673859
Bathina S, Das UN (2015) Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 11(6):1164–1178
doi: 10.5114/aoms.2015.56342
pubmed: 26788077
pmcid: 4697050
Coskunoglu A, Orenay-Boyacioglu S, Deveci A et al (2017) Evidence of associations between brain-derived neurotrophic factor (BDNF) serum levels and gene polymorphisms with tinnitus. Noise Health 19(88):140–148
doi: 10.4103/nah.NAH_74_16
pubmed: 28615544
pmcid: 5501024
Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T (2007) Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90(3):397–406
doi: 10.1016/j.ygeno.2007.05.004
pubmed: 17629449
Adachi N, Numakawa T, Richards M, Nakajima S, Kunugi H (2014) New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases. World J Biol Chem 5(4):409–428
doi: 10.4331/wjbc.v5.i4.409
pubmed: 25426265
pmcid: 4243146
Xie X, Shang K, Li X (2020) Tuling Wendan Decoction combined with flunarizine in the treatment of migraine patients and the effect of intervention on serum cyclooxygenase-2, endothelin-1 and nitric oxide. Cell Mol Biol (Noisy-le-grand) 66(6):34–40
doi: 10.14715/cmb/2020.66.6.7
pubmed: 33040782
Li M, Xie Y, Niu K, Li K (2020) Electroacupuncture ameliorates post-traumatic stress disorder in rats via a mechanism involving the BDNF-TrkB signaling pathway. Cell Mol Biol (Noisy-le-grand) 66(3):165–170
doi: 10.14715/cmb/2020.66.3.26
pubmed: 32538765
Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M, Persson H (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10(3):475–489
doi: 10.1016/0896-6273(93)90335-O
pubmed: 8461137
Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85(3):525–535
doi: 10.1002/jnr.21139
pubmed: 17149751
Amirahmadi S, Hosseini M, Ahmadabady S, Akbarian M, Abrari K, Vafaee F, Rajabian A (2021) Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats. Metab Brain Dis 36(8):2393–2403
doi: 10.1007/s11011-021-00815-3
pubmed: 34562187
Strupp BJ, Powers BE, Velazquez R et al (2016) Maternal choline supplementation: a potential prenatal treatment for down syndrome and Alzheimer’s disease. Curr Alzheimer Res 13(1):97–106
doi: 10.2174/1567205012666150921100311
pubmed: 26391046
pmcid: 4733524
Rashidi Molaei R, Kazemi A, Rahmati M (2016) The effect of a 6-week endurance training on BDNF and TrKB gene expression in the soleus of rats with diabetic neuropathy. J Kerman Univ Med Sci 23(6):741–753
Gil-Ibáñez P, Bernal J, Morte B (2014) Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids. PLoS ONE 9(3):e91692
doi: 10.1371/journal.pone.0091692
pubmed: 24618783
pmcid: 3950245
Herwig A, Campbell G, Mayer CD et al (2014) A thyroid hormone challenge in hypothyroid rats identifies T3 regulated genes in the hypothalamus and in models with altered energy balance and glucose homeostasis. Thyroid 24(11):1575–1593
doi: 10.1089/thy.2014.0169
pubmed: 25087834
pmcid: 4229697
Tiffon C (2018) The impact of nutrition and environmental epigenetics on human health and disease. Int J Mol Sci 19(11):3425
doi: 10.3390/ijms19113425
pubmed: 30388784
pmcid: 6275017
Liu D, Teng W, Shan Z et al (2010) The effect of maternal subclinical hypothyroidism during pregnancy on brain development in rat offspring. Thyroid 20(8):909–915
doi: 10.1089/thy.2009.0036
pubmed: 20615128
Marrocco J, McEwen BS (2016) Sex in the brain: hormones and sex differences. Dialogues Clin Neurosci 18(4):373–383
doi: 10.31887/DCNS.2016.18.4/jmarrocco
pubmed: 28179809
pmcid: 5286723