Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against

Adult Humans Haemophilus influenzae type b Opsonization Antibodies, Bacterial Haemophilus Infections Complement System Proteins
Haemophilus influenzae type b alternative pathway (AP) complement inhibitors immunotherapy opsonophagocytosis serum bactericidal activity (SBA) vaccination

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 16 08 2022
accepted: 25 10 2022
entrez: 29 12 2022
pubmed: 30 12 2022
medline: 31 12 2022
Statut: epublish

Résumé

Defense against

Identifiants

DOI: 10.3389/fimmu.2022.1020580 PMID: 36578495 PMC: PMC9791579
pubmed: 36578495
doi: 10.3389/fimmu.2022.1020580
pmc: PMC9791579
doi:

Substances chimiques

Antibodies, Bacterial 0
Complement System Proteins 9007-36-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1020580

Informations de copyright

Copyright © 2022 Muri, Schubart, Thorburn, Zamurovic, Holbro, Kammüller, Pluschke and Ispasanie.

Déclaration de conflit d'intérêts

Authors AS, CT, NZ, TH and MK were employed by Novartis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Lukas Muri (L)

Molecular Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Anna Schubart (A)

Department Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Christine Thorburn (C)

Novartis Pharma AG, London, United Kingdom.

Natasa Zamurovic (N)

Translational Medicine-Preclinical Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Thomas Holbro (T)

Global Drug Development, Novartis Pharma AG, Basel, Switzerland.

Michael Kammüller (M)

Translational Medicine-Preclinical Safety, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Gerd Pluschke (G)

Molecular Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Emma Ispasanie (E)

Molecular Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Inhibition of the different complement...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of the different complement...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pasteurellaceae › Haemophilus › Haemophilus influenzae › Haemophilus influenzae type B › Inhibition of the different complement...
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › Opsonisation › Inhibition of the different complement...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antibactériens › Inhibition of the different complement...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Pasteurellaceae › Infections à Haemophilus › Inhibition of the different complement...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Inhibition of the different complement...