Humoral response in Leishmaniasis.

Humans Leishmaniasis Leishmaniasis, Visceral Leishmaniasis, Cutaneous Immunity, Humoral Antibodies
B lymphocytes Leishmania complement system humoral response leishmaniasis

Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2022
Historique:
received: 06 10 2022
accepted: 14 11 2022
entrez: 29 12 2022
pubmed: 30 12 2022
medline: 31 12 2022
Statut: epublish

Résumé

Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host's immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection.

Identifiants

DOI: 10.3389/fcimb.2022.1063291 PMID: 36579347 PMC: PMC9791258
pubmed: 36579347
doi: 10.3389/fcimb.2022.1063291
pmc: PMC9791258
doi:

Substances chimiques

Antibodies 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1063291

Informations de copyright

Copyright © 2022 Conde, Maciel, de Assis, Freire-de-Lima, Nico, Vale, Freire-de-Lima and Morrot.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Luciana Conde (L)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Gabriela Maciel (G)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Gustavo Meira de Assis (GM)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Leonardo Freire-de-Lima (L)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Dirlei Nico (D)

Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

André Vale (A)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Célio Geraldo Freire-de-Lima (CG)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Alexandre Morrot (A)

Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Humoral response in Leishmaniasis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Dermatoses parasitaires › Leishmaniose › Humoral response in Leishmaniasis.
questionsmedicales.fr › Infection › Maladies vectorielles › Leishmaniose viscérale › Humoral response in Leishmaniasis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Dermatoses parasitaires › Leishmaniose › Leishmaniose cutanée › Humoral response in Leishmaniasis.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité humorale › Humoral response in Leishmaniasis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Humoral response in Leishmaniasis.