Experimental animal models for brain abscess: a systematic review.

BACKGROUND

Brain abscess (BA) is a rare, but severe infection and experimental BA animal models may prove crucial for advances in treatment. This review describes the development of experimental BA models and the clinical advances obtained from these, in a historical perspective.

MATERIAL AND METHODS

Experimental BA studies from inception until June 15, 2022, were included by searching the PubMed and Embase databases. Inclusion required the use of an experimental BA animal model. Non-bacterial BA models,

RESULTS

79 studies were included. The majority of animal BA models have been based on small rodents using

CONCLUSIONS

Animal models have been vital for improvements in the management of BA. Experimental BA models resembling human disease including polymicrobial infection by oral cavity flora in large animals are needed.