Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia.
miRNA
placenta
preeclampsia
renin–angiotensin–aldosterone system
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
25
04
2022
accepted:
18
07
2022
revised:
14
07
2022
pubmed:
30
12
2022
medline:
17
2
2023
entrez:
29
12
2022
Statut:
ppublish
Résumé
Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin-angiotensin-aldosterone system (RAAS) is one of the first to recognize pregnancy and is an important regulator of blood pressure. The placenta has its own RAAS, the role of which in the development of PE is not fully understood. In this work, for the first time, we characterized the expression of RAAS components and miRNAs controlling it in the placenta at various times of PE manifestation. The data obtained will allow the development of a new strategy in the future for the search for therapeutic agents for patients suffering from PE and cardiovascular diseases.
Identifiants
pubmed: 36580212
doi: 10.1134/S1607672922060011
pii: 10.1134/S1607672922060011
pmc: PMC9928934
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
256-263Informations de copyright
© 2022. The Author(s).
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