Design of a Patient-Specific Respiratory-Motion-Simulating Platform for In Vitro 4D Flow MRI.
4D flow MRI
In vitro and in vivo
Liver motion
Respiratory-motion-simulating platform
Signal-to-noise ratio
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
23
03
2022
accepted:
04
12
2022
medline:
25
4
2023
pubmed:
30
12
2022
entrez:
29
12
2022
Statut:
ppublish
Résumé
Four-dimensional (4D) flow magnetic resonance imaging (MRI) is a leading-edge imaging technique and has numerous medicinal applications. In vitro 4D flow MRI can offer some advantages over in vivo ones, especially in accurately controlling flow rate (gold standard), removing patient and user-specific variations, and minimizing animal testing. Here, a complete testing method and a respiratory-motion-simulating platform are proposed for in vitro validation of 4D flow MRI. A silicon phantom based on the hepatic arteries of a living pig is made. Under the free-breathing, a human volunteer's liver motion (inferior-superior direction) is tracked using a pencil-beam MRI navigator and is extracted and converted into velocity-distance pairs to program the respiratory-motion-simulating platform. With the magnitude displacement of about 1.3 cm, the difference between the motions obtained from the volunteer and our platform is ≤ 1 mm which is within the positioning error of the MRI navigator. The influence of the platform on the MRI signal-to-noise ratio can be eliminated even if the actuator is placed in the MRI room. The 4D flow measurement errors are respectively 0.4% (stationary phantom), 9.4% (gating window = 3 mm), 27.3% (gating window = 4 mm) and 33.1% (gating window = 7 mm). The vessel resolutions decreased with the increase of the gating window. The low-cost simulation system, assembled from commercially available components, is easy to be duplicated.
Identifiants
pubmed: 36580223
doi: 10.1007/s10439-022-03117-6
pii: 10.1007/s10439-022-03117-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1028-1039Subventions
Organisme : Canadian Institute of Health Research
ID : 202003PJT-437727-MPI-ADWY-19089
Organisme : National Natural Science Foundation of China
ID : 61973207
Organisme : Shanghai Rising-Star Program
ID : 20QA1403900
Informations de copyright
© 2022. The Author(s) under exclusive licence to Biomedical Engineering Society.
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