Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia.
Central Nervous System Sensitization
Chronic Pain
Fibromyalgia
Functional Neuroimaging
Magnetic Resonance Imaging
Neural Pathways
Pain Perception
Periaqueductal Gray
Psychophysics
Somatosensory Cortex.
Journal
The Korean journal of pain
ISSN: 2005-9159
Titre abrégé: Korean J Pain
Pays: Korea (South)
ID NLM: 101528125
Informations de publication
Date de publication:
01 Jan 2023
01 Jan 2023
Historique:
received:
04
07
2022
revised:
09
11
2022
accepted:
09
11
2022
entrez:
29
12
2022
pubmed:
30
12
2022
medline:
30
12
2022
Statut:
ppublish
Résumé
Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders ( Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) ( These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.
Sections du résumé
Background
UNASSIGNED
Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life.
Methods
UNASSIGNED
This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (
Results
UNASSIGNED
Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (
Conclusions
UNASSIGNED
These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.
Identifiants
pubmed: 36581601
pii: kjp.22225
doi: 10.3344/kjp.22225
pmc: PMC9812696
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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