Modulating mental state recognition by anodal tDCS over the cerebellum.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 12 2022
30 12 2022
Historique:
received:
07
06
2022
accepted:
21
12
2022
entrez:
30
12
2022
pubmed:
31
12
2022
medline:
4
1
2023
Statut:
epublish
Résumé
Increasing evidence from neuroimaging and clinical studies has demonstrated cerebellar involvement in social cognition components, including the mentalizing process. The aim of this study was to apply transcranial direct current stimulation (tDCS) to modulate cerebellar excitability to investigate the role the cerebellum plays in mental state recognition. Forty-eight healthy subjects were randomly assigned to different groups in which anodal, cathodal, or sham tDCS (2 mA for 20 min) was delivered centering the electrode on the vermis to stimulate the posterior portion of the cerebellum. The ability to attribute mental states to others was tested before and after tDCS using a digital version of the 'Reading the Mind in the Eyes test', which includes visual perceptive and motor stimuli as control conditions. Correct response and reaction times (RTs) were recorded. The results revealed a significant reduction in RTs between the baseline and post-stimulation sessions after cerebellar anodal tDCS only for mental state stimuli (Wilcoxon test p = 0.00055), whereas no significant effect was found in the cathodal or sham conditions or for visual perceptive and motor stimuli. Overall, our study suggests that cerebellar anodal tDCS might selectively improve mental state recognition and constitute an effective strategy to positively modulate the mentalizing process.
Identifiants
pubmed: 36585436
doi: 10.1038/s41598-022-26914-4
pii: 10.1038/s41598-022-26914-4
pmc: PMC9803656
doi:
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22616Informations de copyright
© 2022. The Author(s).
Références
Autism Res. 2021 Nov;14(11):2300-2313
pubmed: 34374492
Cerebellum. 2016 Dec;15(6):732-743
pubmed: 26585120
Suppl Clin Neurophysiol. 2003;56:255-76
pubmed: 14677403
Cerebellum. 2017 Apr;16(2):552-576
pubmed: 27485952
J Cogn Neurosci. 2008 Sep;20(9):1687-97
pubmed: 18345990
Cortex. 2021 May;138:101-112
pubmed: 33677324
Nat Neurosci. 2017 Dec;20(12):1744-1751
pubmed: 29184200
Cerebellum. 2013 Aug;12(4):485-92
pubmed: 23328908
Front Neurosci. 2019 Mar 12;13:198
pubmed: 30914915
Cerebellum. 2022 Aug;21(4):592-605
pubmed: 35334077
IEEE Int Conf Rehabil Robot. 2019 Jun;2019:1191-1196
pubmed: 31374791
Perspect Psychol Sci. 2020 Mar;15(2):384-396
pubmed: 32069168
Neuroimage. 2014 Jan 15;85 Pt 3:918-23
pubmed: 23664951
Nurs Res. 1989 Sep-Oct;38(5):286-8
pubmed: 2678015
Psychiatry Res Neuroimaging. 2019 Jan 30;283:24-33
pubmed: 30500474
J Physiol. 2013 May 15;591(10):2563-78
pubmed: 23478132
Cerebellum. 2020 Apr;19(2):235-242
pubmed: 31925668
Cerebellum. 2019 Dec;18(6):1064-1097
pubmed: 31165428
Cerebellum. 2012 Sep;11(3):777-807
pubmed: 22370873
J Psychiatry Neurosci. 2009 Jan;34(1):60-5
pubmed: 19125214
Sci Rep. 2019 Jul 31;9(1):11110
pubmed: 31366954
PLoS Comput Biol. 2021 Dec 9;17(12):e1009609
pubmed: 34882680
Front Hum Neurosci. 2012 Jun 21;6:189
pubmed: 22737119
J Physiol. 1991 Sep;441:57-72
pubmed: 1816387
Cerebellum. 2017 Jun;16(3):695-741
pubmed: 28032321
Front Neurosci. 2019 Apr 12;13:266
pubmed: 31031578
Neurosci Biobehav Rev. 2016 Jun;65:276-91
pubmed: 27073047
Brain. 2006 Feb;129(Pt 2):290-2
pubmed: 16434422
J Neurosci. 2003 Sep 10;23(23):8432-44
pubmed: 12968006
Neuroimage. 2009 Nov 15;48(3):564-84
pubmed: 19524046
Cogn Emot. 2012;26(5):786-99
pubmed: 22077643
J Neurosci. 2001 Jan 15;21(2):700-12
pubmed: 11160449
Trends Cogn Sci. 2017 May;21(5):313-332
pubmed: 28385461
Cogn Affect Behav Neurosci. 2019 Feb;19(1):211-223
pubmed: 30361864
Front Integr Neurosci. 2022 Jan 28;16:810425
pubmed: 35153691
J Cogn Neurosci. 1992 Spring;4(2):107-18
pubmed: 23967887
J Abnorm Psychol. 2016 Aug;125(6):818-823
pubmed: 27505409
Clin Neurophysiol. 2014 Mar;125(3):577-84
pubmed: 24176297
Clin Neurophysiol. 2017 Sep;128(9):1774-1809
pubmed: 28709880
Neuroscience. 2009 Sep 1;162(3):827-35
pubmed: 19409211
Brain. 2011 Dec;134(Pt 12):3672-86
pubmed: 22036960
Nat Rev Neurosci. 2006 Jul;7(7):511-22
pubmed: 16791141
J Neural Eng. 2019 Jun;16(3):036001
pubmed: 30808008
Cerebellum. 2018 Apr;17(2):228-236
pubmed: 28786014
Neuron. 2014 Aug 6;83(3):518-32
pubmed: 25102558
Neuropsychologia. 2005;43(2):294-300
pubmed: 15707913
Hum Brain Mapp. 2015 Dec;36(12):5137-54
pubmed: 26419890
Soc Neurosci. 2015 Aug;10(4):337-44
pubmed: 25621820
Cerebellum. 2020 Feb;19(1):1-5
pubmed: 31707620
Brain Stimul. 2013 Nov;6(6):966-8
pubmed: 23711765
Brain Res Cogn Brain Res. 2004 Apr;19(2):114-22
pubmed: 15019708
Hum Brain Mapp. 2009 Mar;30(3):829-58
pubmed: 18381770
J Child Psychol Psychiatry. 2001 Feb;42(2):241-51
pubmed: 11280420
Cerebellum. 2020 Dec;19(6):833-868
pubmed: 32632709
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Cerebellum. 2020 Feb;19(1):102-125
pubmed: 31522332
Neuroimage. 2016 Jan 1;124(Pt A):248-255
pubmed: 26348560
J Physiol. 2004 Jun 1;557(Pt 2):689-700
pubmed: 15047772
Handb Clin Neurol. 2018;154:71-84
pubmed: 29903453
Nat Neurosci. 2019 Aug;22(8):1371-1378
pubmed: 31285616
Neuroscience. 2021 May 10;462:288-302
pubmed: 33731315
Brain Struct Funct. 2021 Apr;226(3):671-684
pubmed: 33426567
Neuroimage. 2014 Feb 1;86:554-72
pubmed: 24076206
Cerebellum. 2017 Apr;16(2):283-292
pubmed: 27250977
Nat Rev Neurosci. 2008 Apr;9(4):304-13
pubmed: 18319727
Eur J Neurosci. 2018 Mar;47(6):729-735
pubmed: 29057532
Sci Rep. 2021 Nov 12;11(1):22183
pubmed: 34773062
Stud Rockefeller Inst Med Res Repr. 1947;132:1-548
pubmed: 20261884
Front Neurol. 2020 Feb 25;11:82
pubmed: 32161564
Front Cell Neurosci. 2019 Jan 08;12:510
pubmed: 30670949
Neuropsychologia. 2022 May 3;169:108206
pubmed: 35278462
Neuroscientist. 2016 Feb;22(1):83-97
pubmed: 25406224
Front Hum Neurosci. 2016 May 11;10:199
pubmed: 27242469
Neuroimage. 2018 May 15;172:437-449
pubmed: 29408539
Cerebellum. 2022 Jun;21(3):482-496
pubmed: 34270081
Cerebellum. 2014 Feb;13(1):121-38
pubmed: 23943521
Int Rev Neurobiol. 1997;41:31-60
pubmed: 9378595
IEEE Trans Neural Syst Rehabil Eng. 2014 May;22(3):441-52
pubmed: 24760939
Brain Stimul. 2013 Jul;6(4):649-53
pubmed: 23122917
Science. 1977 Oct 7;198(4312):74-8
pubmed: 897687
Neuroimage. 2021 Feb 1;226:117582
pubmed: 33221449