Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology - secondary publication.

Humans Anaphylaxis / diagnosis East Asian People Epinephrine / therapeutic use Japan / epidemiology Registries
Adrenaline Anaphylaxis Drug hypersensitivity Food hypersensitivity Insect allergy

Journal

Allergology international : official journal of the Japanese Society of Allergology
ISSN: 1440-1592
Titre abrégé: Allergol Int
Pays: England
ID NLM: 9616296

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 08 11 2022
accepted: 27 11 2022
medline: 28 6 2023
pubmed: 2 1 2023
entrez: 1 1 2023
Statut: ppublish

Résumé

Anaphylaxis is a potentially fatal severe systemic hypersensitivity reaction that causes symptoms in multiple organs such as the skin, respiratory tract, and gastrointestinal tract; however, no nationwide epidemiological survey on anaphylaxis has been conducted in Japan. This survey aimed to elucidate the triggers and treatment of anaphylaxis in Japan. Between February 2015 and October 2017, we prospectively collected clinical data on the triggers and treatment of patients who developed anaphylaxis or were admitted to the emergency room with anaphylaxis in the training and teaching facilities of the Japanese Society of Allergology. This study included 79 of the 451 affiliated facilities (18%), and a total of 767 patients were enrolled; 73% of them were aged <18 years and 7% had in-hospital triggers. The most common triggers were food (68%), drugs (12%), food-dependent exercise-induced anaphylaxis (5%), insects (4%), and oral immunotherapy (3%), with drugs being the most common in-hospital trigger and food being the most common out-of-hospital trigger. Intramuscular injection of adrenaline was administered therapeutically to 38% of the patients, with 10% requiring multiple doses. Adrenaline auto-injectors were used in 12% of out-of-hospital patients. The present survey revealed the most common triggers and treatments for anaphylaxis in Japan. Self-management and adrenaline administration as first-line treatment may not be done sufficiently. Therefore, it is necessary to thoroughly educate and train patients and physicians about anaphylaxis.

Sections du résumé

BACKGROUND BACKGROUND
Anaphylaxis is a potentially fatal severe systemic hypersensitivity reaction that causes symptoms in multiple organs such as the skin, respiratory tract, and gastrointestinal tract; however, no nationwide epidemiological survey on anaphylaxis has been conducted in Japan. This survey aimed to elucidate the triggers and treatment of anaphylaxis in Japan.
METHODS METHODS
Between February 2015 and October 2017, we prospectively collected clinical data on the triggers and treatment of patients who developed anaphylaxis or were admitted to the emergency room with anaphylaxis in the training and teaching facilities of the Japanese Society of Allergology.
RESULTS RESULTS
This study included 79 of the 451 affiliated facilities (18%), and a total of 767 patients were enrolled; 73% of them were aged <18 years and 7% had in-hospital triggers. The most common triggers were food (68%), drugs (12%), food-dependent exercise-induced anaphylaxis (5%), insects (4%), and oral immunotherapy (3%), with drugs being the most common in-hospital trigger and food being the most common out-of-hospital trigger. Intramuscular injection of adrenaline was administered therapeutically to 38% of the patients, with 10% requiring multiple doses. Adrenaline auto-injectors were used in 12% of out-of-hospital patients.
CONCLUSIONS CONCLUSIONS
The present survey revealed the most common triggers and treatments for anaphylaxis in Japan. Self-management and adrenaline administration as first-line treatment may not be done sufficiently. Therefore, it is necessary to thoroughly educate and train patients and physicians about anaphylaxis.

Identifiants

DOI: 10.1016/j.alit.2022.12.003 PMID: 36588001
pubmed: 36588001
pii: S1323-8930(22)00140-X
doi: 10.1016/j.alit.2022.12.003
pii:
doi:

Substances chimiques

Epinephrine YKH834O4BH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

437-443

Informations de copyright

Copyright © 2022 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.

Auteurs

Sakura Sato (S)

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.

Noriyuki Yanagida (N)

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.

Komei Ito (K)

Department of Allergy, Aichi Children's Health and Medical Center, Obu, Japan.

Yoshitaka Okamoto (Y)

Department of Otorhinolaryngology, Chiba Rosai Hospital, Chiba, Japan.

Hirohisa Saito (H)

Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

Masami Taniguchi (M)

Department of Allergy, Shonan Kamakura General Hospital, Kanagawa, Japan.

Makoto Nagata (M)

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University Hospital, Saitama, Japan.

Hirokuni Hirata (H)

Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

Masao Yamaguchi (M)

Department of Internal Medicine, Teikyo University Chiba Medical Center, Chiba, Japan.

Ruby Pawankar (R)

Department of Pediatrics, Nippon Medical School, Tokyo, Japan.

Motohiro Ebisawa (M)

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan. Electronic address: mebisawa@foodallergy.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Current situation of anaphylaxis in Japan:...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Anaphylaxie › Current situation of anaphylaxis in Japan:...
questionsmedicales.fr › Personnes › Asiatiques › Peuples d'Asie de l'Est › Current situation of anaphylaxis in Japan:...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Épinéphrine › Current situation of anaphylaxis in Japan:...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Current situation of anaphylaxis in Japan:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Current situation of anaphylaxis in Japan:...