Novel optical coherence tomography angiography biomarkers in the diagnosis and assessment of diabetic macular edema and diabetic macular ischemia in patients with non-proliferative diabetic retinopathy.
Diabetic macular edema (DME)
diabetic macular ischemia (DMI)
diabetic retinopathy (DR)
foveal avascular zone (FAZ)
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
4
1
2023
Statut:
ppublish
Résumé
The present study aims to determine the macular and choroidal optical coherence tomography angiography (OCTA) biomarkers in the assessment and monitoring of diabetic macular edema (DME) and diabetic macular ischemia (DMI) in patients with non-proliferative diabetic retinopathy (NPDR). In this cohort study, a total of 176 eyes of 110 patients with NPDR were investigated at our institute over a period of 10 months. Eyes were divided into four groups based on the severity of NPDR. Each eye was subjected to OCTA (Topcon 3D OCT-1 Maestro2) macula 6 × 6 mm Increase in FAZ area and number of CDA were statistically significant (p < 0.0001) with an increase in central foveal thickness, suggesting a correlation of ischemic changes with an increase in DME. FAZ-CI, enlarged PICA, and CCFV were significantly associated with more severe NPDR patients. A correlation between DME and DMI in a patient of NPDR and its progression can be evaluated in a single visit. A unique feature of our study is it revealed novel diagnostic biomarkers of OCTA for DMI and DME.
Identifiants
pubmed: 36588233
pii: IndianJOphthalmol_2023_71_1_183_366008
doi: 10.4103/ijo.IJO_1294_22
pmc: PMC10155526
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
183-187Références
Acta Ophthalmol (Copenh). 1994 Aug;72(4):409-15
pubmed: 7825403
Ophthalmology. 2003 Sep;110(9):1677-82
pubmed: 13129861
PLoS One. 2019 Jun 4;14(6):e0217849
pubmed: 31163058
Br J Ophthalmol. 1991 Sep;75(9):514-8
pubmed: 1911651
N Engl J Med. 2010 Jul 15;363(3):233-44
pubmed: 20587587
Int J Ophthalmol. 2017 Oct 18;10(10):1545-1551
pubmed: 29062774
Ophthalmology. 2019 Dec;126(12):1675-1684
pubmed: 31358386
Br J Ophthalmol. 2021 Jun;105(6):812-818
pubmed: 32703785
Ophthalmology. 2017 Feb;124(2):235-244
pubmed: 27887743
Ophthalmic Res. 2019;62(4):203-210
pubmed: 31013506
Retina. 2020 Feb;40(2):322-332
pubmed: 31972803
Arch Ophthalmol. 1961 Sep;66:366-78
pubmed: 13694291
Sci Rep. 2017 Jul 12;7(1):5227
pubmed: 28701715
Diabetes Res Clin Pract. 2014 Feb;103(2):150-60
pubmed: 24300018
J Diabet Complications. 1988 Jul-Sep;2(3):117-20
pubmed: 2975659
Mol Aspects Med. 2012 Aug;33(4):295-317
pubmed: 22542780
J Anat. 1999 Jan;194 ( Pt 1):89-100
pubmed: 10227670
Arch Ophthalmol. 1984 Sep;102(9):1286-93
pubmed: 6477244
JAMA Ophthalmol. 2015 Jan;133(1):45-50
pubmed: 25317632
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6729-34
pubmed: 20631236