The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates.
ASGPR
GalNAc-siRNA
LNPs
RNAi
delivery system
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
11
2022
accepted:
05
12
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
RNA interference has become increasingly used for genetic therapy following the rapid development of oligonucleotide drugs. Significant progress has been made in its delivery system and implementation in the treatment of target organs. After a brief introduction of RNA interference technology and siRNA, the efficiency and stability of GalNAc-siRNA conjugates are highlighted since several oligonucleotide drugs of GalNAc have been approved for clinical use in recent years. The structure and features of GalNAc-siRNA conjugates are studied and the clinical efficiency and limitations of oligonucleotide-based drugs are summarized and investigated. Furthermore, another delivery system, lipid nanoparticles, that confer many advantages, is concluded, includ-ing stability and mass production, compared with GalNAc-siRNA conjugates. Importantly, developing new approaches for the use of oligonucleotide drugs brings hope to genetic therapy.
Identifiants
pubmed: 36588695
doi: 10.3389/fphar.2022.1090237
pii: 1090237
pmc: PMC9794871
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1090237Informations de copyright
Copyright © 2022 Zhang, Liang, Liang, Tian, Zhang, Liu and Ji.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biochem Pharmacol. 2021 Jul;189:114374
pubmed: 33358826
Bioeng Transl Med. 2021 Mar 20;6(2):e10213
pubmed: 33786376
J Am Soc Nephrol. 2017 Feb;28(2):494-503
pubmed: 27432743
Mol Ther. 2021 Oct 6;29(10):2910-2919
pubmed: 34091052
Drugs R D. 2021 Dec;21(4):455-465
pubmed: 34741731
Drugs. 2022 Sep;82(13):1419-1425
pubmed: 35997942
Nat Biomed Eng. 2021 Sep;5(9):1059-1068
pubmed: 34616046
Eur J Pharmacol. 2020 Jul 5;878:173114
pubmed: 32302598
Mol Ther Nucleic Acids. 2021 Dec 3;26:997-1013
pubmed: 34540356
Drugs. 2021 Feb;81(2):277-282
pubmed: 33405070
N Engl J Med. 2017 Aug 31;377(9):862-872
pubmed: 28854095
Nucleic Acid Ther. 2021 Feb;31(1):21-38
pubmed: 33121373
Methods Mol Biol. 2010;640:281-94
pubmed: 20645058
Nucleic Acid Ther. 2018 Jun;28(3):109-118
pubmed: 29792572
Pharmaceutics. 2021 Feb 02;13(2):
pubmed: 33540942
Bio Protoc. 2021 Oct 05;11(19):e4184
pubmed: 34722830
Sci China Life Sci. 2020 Apr;63(4):485-500
pubmed: 31054052
Pharmacoeconomics. 2020 Sep;38(9):1007-1020
pubmed: 32789593
J Am Heart Assoc. 2015 Jan 05;4(1):e001138
pubmed: 25559010
Biotechnol Adv. 2019 Sep - Oct;37(5):801-825
pubmed: 31034960
JHEP Rep. 2021 Apr 30;3(4):100300
pubmed: 34159305
Mol Ther Nucleic Acids. 2018 Mar 2;10:237-244
pubmed: 29499936
Biochim Biophys Acta Gene Regul Mech. 2021 Jun-Jul;1864(6-7):194704
pubmed: 33895310
Mol Ther. 2018 Mar 7;26(3):708-717
pubmed: 29456020
Front Cardiovasc Med. 2021 Nov 17;8:789931
pubmed: 34869702
Acc Chem Res. 2022 Jan 4;55(1):2-12
pubmed: 34850635
Pharm Res. 2022 Aug;39(8):1749-1759
pubmed: 35819583
J Pharmacol Exp Ther. 2021 Nov;379(2):134-146
pubmed: 34413198
Nucleic Acids Res. 2021 Oct 11;49(18):10250-10264
pubmed: 34508350
Hum Gene Ther. 2015 Aug;26(8):475-85
pubmed: 26160334
J Control Release. 2021 Oct 10;338:201-210
pubmed: 34418521
Drugs. 2018 Oct;78(15):1625-1631
pubmed: 30251172
Nat Nanotechnol. 2021 Jun;16(6):630-643
pubmed: 34059811
Commun Biol. 2021 Aug 11;4(1):956
pubmed: 34381159
Nat Commun. 2018 Feb 19;9(1):723
pubmed: 29459660
Methods Mol Biol. 2018;1706:293-302
pubmed: 29423805
J Pharm Sci. 2011 Jan;100(1):38-52
pubmed: 20575003
Chem Rev. 2021 Oct 27;121(20):12181-12277
pubmed: 34279087
Diabetes Care. 2019 Jan;42(1):173-176
pubmed: 30487231
J Clin Transl Hepatol. 2015 Mar;3(1):17-26
pubmed: 26357631
Nat Biotechnol. 2013 Jul;31(7):638-46
pubmed: 23792630
RSC Adv. 2021 Jan 11;11(4):2415-2426
pubmed: 35424193
Biochemistry. 2021 May 4;60(17):1327-1336
pubmed: 33724805
J Clin Endocrinol Metab. 2022 Apr 19;107(5):1216-1224
pubmed: 34888679
Cancers (Basel). 2021 Aug 01;13(15):
pubmed: 34359781
Clin Pharmacol Ther. 2021 Feb;109(2):372-382
pubmed: 32599652
Mol Diagn Ther. 2020 Feb;24(1):61-68
pubmed: 31792921
Adv Drug Deliv Rev. 2017 Jun 1;115:98-114
pubmed: 28396204
Eur J Pharmacol. 2022 Feb 5;916:174741
pubmed: 34998574
Front Pharmacol. 2021 Mar 16;12:644718
pubmed: 33796026
Expert Opin Drug Metab Toxicol. 2021 Dec;17(12):1353-1361
pubmed: 35025707
N Engl J Med. 2020 Jun 11;382(24):2289-2301
pubmed: 32521132
Curr Pharm Des. 2018;24(23):2692-2700
pubmed: 30084326
Nucleic Acids Res. 2017 Nov 2;45(19):10969-10977
pubmed: 28981809
Liver Int. 2022 Jan;42(1):161-172
pubmed: 34717041
J Am Chem Soc. 2014 Dec 10;136(49):16958-61
pubmed: 25434769
Pharmacol Res. 2021 Nov;173:105864
pubmed: 34474100
Clin Genet. 1991 Sep;40(3):242-6
pubmed: 1685359
J Control Release. 2021 Jul 10;335:237-246
pubmed: 34019945
Biomed Pharmacother. 2021 Nov;143:112227
pubmed: 34563953
Biochem Pharmacol. 2021 Jul;189:114432
pubmed: 33513339
Front Bioeng Biotechnol. 2021 Mar 18;9:628137
pubmed: 33816449
BioDrugs. 2020 Feb;34(1):1-9
pubmed: 31782112
NAR Cancer. 2021 Jul 20;3(3):zcab030
pubmed: 34316717
Nature. 2002 Jul 11;418(6894):244-51
pubmed: 12110901
Sci Rep. 2016 Sep 08;6:32301
pubmed: 27604151
Amyloid. 2022 Jul 23;:1-9
pubmed: 35875890
Adv Drug Deliv Rev. 2021 Jul;174:576-612
pubmed: 34019958
J Thromb Haemost. 2021 Jun;19(6):1436-1446
pubmed: 33587824
Nucleic Acids Res. 2020 Dec 2;48(21):11827-11844
pubmed: 32808038
Adv Drug Deliv Rev. 2021 Aug;175:113809
pubmed: 34033819
ACS Omega. 2021 Jun 14;6(25):16259-16265
pubmed: 34235295
Mol Ther Nucleic Acids. 2019 Jun 7;16:326-334
pubmed: 30965277
Adv Drug Deliv Rev. 2021 Nov;178:113974
pubmed: 34530015
Nucleic Acid Ther. 2020 Feb;30(1):33-49
pubmed: 31821125
Nat Rev Drug Discov. 2019 Jun;18(6):421-446
pubmed: 30846871
Nat Rev Drug Discov. 2021 Nov;20(11):817-838
pubmed: 34433919
Clin J Am Soc Nephrol. 2021 Jul;16(7):1025-1036
pubmed: 33985991
Pharmaceutics. 2021 Jan 26;13(2):
pubmed: 33530309
Curr Opin Colloid Interface Sci. 2021 Oct;55:101468
pubmed: 34093062
Nucleic Acid Ther. 2018 Jun;28(3):166-177
pubmed: 29708838
Nat Rev Genet. 2022 May;23(5):265-280
pubmed: 34983972
Expert Opin Drug Deliv. 2019 Nov;16(11):1205-1226
pubmed: 31530041
Biochem Biophys Res Commun. 2004 Apr 9;316(3):680-7
pubmed: 15033453
Kidney Int Rep. 2021 Apr 15;6(7):1904-1911
pubmed: 34307985
Mol Ther. 2018 Jan 3;26(1):105-114
pubmed: 28988716
Viruses. 2018 May 01;10(5):
pubmed: 29723993
Biomedicines. 2021 May 14;9(5):
pubmed: 34068948
Mol Ther. 2020 Aug 5;28(8):1759-1771
pubmed: 32592692
N Engl J Med. 2021 Apr 1;384(13):1216-1226
pubmed: 33789010
J Biol Chem. 1985 Sep 25;260(21):11793-8
pubmed: 4044580
Future Cardiol. 2018 Nov;14(6):433-442
pubmed: 30375244
Adv Healthc Mater. 2021 Aug;10(15):e2002022
pubmed: 33661555
Drugs. 2020 Feb;80(3):335-339
pubmed: 32034693
FEBS Lett. 2014 Aug 1;588(15):2550-6
pubmed: 24873877
Adv Drug Deliv Rev. 2021 Nov;178:113834
pubmed: 34492233
Clin Pharmacol Ther. 2020 Jul;108(1):63-72
pubmed: 31994716
Toxicol Pathol. 2018 Oct;46(7):735-745
pubmed: 30139307
Drugs. 2021 Feb;81(3):389-395
pubmed: 33620677
Mol Ther. 2016 Apr;24(4):770-8
pubmed: 26758691
Nanomaterials (Basel). 2018 Apr 24;8(5):
pubmed: 29695068
Pharmacol Ther. 2022 Feb;230:107967
pubmed: 34403681
Bioconjug Chem. 2019 Feb 20;30(2):366-383
pubmed: 30608140
Eur J Med Chem. 2022 Jan 5;227:113910
pubmed: 34689071
ACS Chem Biol. 2015 May 15;10(5):1181-7
pubmed: 25730476
Cell Metab. 2018 Apr 3;27(4):714-739
pubmed: 29617640
Signal Transduct Target Ther. 2020 Jun 19;5(1):101
pubmed: 32561705
Adv Drug Deliv Rev. 2021 Jul;174:53-86
pubmed: 33539852
Kidney Int Rep. 2021 Sep 17;6(12):2942-2957
pubmed: 34901567
Mol Cell. 2022 Jan 6;82(1):30-43
pubmed: 34942118
Am J Cardiovasc Drugs. 2021 Nov;21(6):629-642
pubmed: 33954930
ACS Cent Sci. 2021 Mar 24;7(3):499-506
pubmed: 33791431
J Control Release. 2022 Feb;342:241-279
pubmed: 35016918
Adv Drug Deliv Rev. 2021 Jan;168:30-54
pubmed: 32246984
Acc Chem Res. 2021 Dec 7;54(23):4283-4293
pubmed: 34793124
J Control Release. 2021 Feb 10;330:812-820
pubmed: 33417983
Nucleic Acid Ther. 2021 Aug;31(4):298-308
pubmed: 33891483
Nucleic Acids Res. 2021 Nov 8;49(19):10851-10867
pubmed: 34648028
Adv Drug Deliv Rev. 2018 Sep;134:36-50
pubmed: 30321620
J Control Release. 2021 Mar 10;331:121-141
pubmed: 33453339
Life Sci. 2021 Jun 1;274:119337
pubmed: 33713664
Biochem Pharmacol. 2021 Jul;189:114468
pubmed: 33577889