Acetate suppresses myocardial contraction
FFAR2
GPR43
acetate
calcium handling
cardiac contractility
short-chain fatty acids
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
11
2022
accepted:
09
12
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
The heart has high energy requirements, with an estimated 40%-60% of myocardial ATP production derived from the oxidation of fatty acids under physiological conditions. However, the effect of short-chain fatty acids on myocardial contraction remains controversial, warranting further research. The present study sought to investigate the effects and mechanisms of acetate, a short-chain fatty acid, on myocardial contraction in rat ventricular myocytes. Echocardiography and Langendorff heart perfusion were used to evaluate cardiac function. Cell shortening and calcium transient were measured in isolated cardiomyocytes. The patch-clamp method determined the action potential and L-type Ca
Identifiants
pubmed: 36589441
doi: 10.3389/fphys.2022.1111156
pii: 1111156
pmc: PMC9800787
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1111156Informations de copyright
Copyright © 2022 Jiang, Zhang, Zhang, Zhang, Yin, Yuan, Wang and Tian.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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