Neural recovery after cortical injury: Effects of MSC derived extracellular vesicles on motor circuit remodeling in rhesus monkeys.
CB, Calbindin
CR, Calretinin
CSC, Cervical Spinal Cord
Circuit Remodeling
Cortical Injury
DH, Dorsal Horn
EVs, Extracellular Vesicles
Extracellular Vesicles
Ischemia
LCST, Lateral Corticospinal Tract
M1, Primary Motor Cortex
MAP2, Microtubule Associated Protein 2
MSCd, Mesenchymal Stem Cell derived
Motor Cortex
NHP, Non-Human Primate
PV, Parvalbumin
Plasticity
ROS, Reactive Oxygen Species
SYN, Synaptophysin
Stem Cell-Based Treatments
VH, Ventral Horn
dPMC, dorsal Premotor Cortex
miRNA, Micro RNA
periM1, Perilesional Primary Motor Cortex
Journal
IBRO neuroscience reports
ISSN: 2667-2421
Titre abrégé: IBRO Neurosci Rep
Pays: Netherlands
ID NLM: 101775148
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
11
02
2022
revised:
01
07
2022
accepted:
07
08
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
Reorganization of motor circuits in the cortex and corticospinal tract are thought to underlie functional recovery after cortical injury, but the mechanisms of neural plasticity that could be therapeutic targets remain unclear. Recent work from our group have shown that systemic treatment with mesenchymal stem cell derived (MSCd) extracellular vesicles (EVs) administered after cortical damage to the primary motor cortex (M1) of rhesus monkeys resulted in a robust recovery of fine motor function and reduced chronic inflammation. Here, we used immunohistochemistry for cfos, an activity-dependent intermediate early gene, to label task-related neurons in the surviving primary motor and premotor cortices, and markers of axonal and synaptic plasticity in the spinal cord. Compared to vehicle, EV treatment was associated with a greater density of cfos
Identifiants
pubmed: 36590089
doi: 10.1016/j.ibneur.2022.08.001
pii: S2667-2421(22)00053-7
pmc: PMC9795302
doi:
Types de publication
Journal Article
Langues
eng
Pagination
243-254Informations de copyright
© 2022 The Authors.
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