Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study.
aging
fibrosis
liver
older population
retina
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
09
2022
accepted:
25
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study. Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score. Increased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96-0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97-0.99; SE: 0.01). Our findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease.
Sections du résumé
Background
UNASSIGNED
Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study.
Methods
UNASSIGNED
Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score.
Results
UNASSIGNED
Increased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96-0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97-0.99; SE: 0.01).
Conclusion
UNASSIGNED
Our findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease.
Identifiants
pubmed: 36590297
doi: 10.3389/fnins.2022.1048375
pmc: PMC9798127
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1048375Investigateurs
Giulia Maria Pia Bisceglia
(GMP)
Rosa Buonamassa
(R)
Flavio Cassano
(F)
Arcangelo Clemente
(A)
Pierfrancesco Digregorio
(P)
Roberta Galati
(R)
Marida Gaudiomonte
(M)
Antonella Guglielmi
(A)
Luca Landini
(L)
Francesca Palumbo
(F)
Pasquale Pasculli
(P)
Giovanni Petruzzella
(G)
Michele Santoro
(M)
Giacomo Scotti
(G)
Roberto Semeraro
(R)
Informations de copyright
Copyright © 2022 Lampignano, Niro, Castellana, Bortone, Zupo, Tirelli, Tatoli, Griseta, De Nucci, Sila, De Pergola, Conte, Alessio, Boscia, Sborgia, Eye Clinic Research Group, Giannelli and Sardone.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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