Livestock-associated methicillin-resistant
LA-MRSA CC398
MRSA
Staphylococcal infection/epidemiology
Staphylococcus aureus
antimicrobial surveillance
cgMLST clustering
one-health
whole-genome sequencing
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
02
2022
accepted:
08
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
While Livestock-associated methicillin-resistant In this retrospective study, we evaluated LA-MRSA strains that were collected between 2014 and 2018 from patients who received clinical care in a single urban area in Netherlands. Patient files were assessed for livestock exposure data, clinical findings, and contact tracing information. Next-generation sequencing (NGS) analysis in combination with wgMLST was conducted to assess genetic diversity and relatedness and to detect virulence and resistance genes. LA-MRSA strains were cultured from 81 patients, comprising 12% of all the MRSA strains found in seven study laboratories between 2014 and 2018. No livestock link was found in 76% of patients ( LA-MRSA may cause a relevant burden of disease in urban areas. Surprisingly, most infections in the present study occurred in the absence of a livestock link, suggesting inter-human transmission. These findings and the presence of PVL and other immune evasive complex virulence genes warrant future surveillance and preventative measures.
Identifiants
pubmed: 36590396
doi: 10.3389/fmicb.2022.875775
pmc: PMC9795226
doi:
Types de publication
Journal Article
Langues
eng
Pagination
875775Informations de copyright
Copyright © 2022 Konstantinovski, Schouls, Witteveen, Claas, Kraakman, Kalpoe, Mattson, Hetem, van Elzakker, Kerremans, Hira, Bosch and Gooskens.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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