Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles.
Immunology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Jan 2023
20 Jan 2023
Historique:
received:
01
11
2022
revised:
04
12
2022
accepted:
20
12
2022
pubmed:
3
1
2023
medline:
3
1
2023
entrez:
2
1
2023
Statut:
ppublish
Résumé
We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a delayed development of neutralization in PLWH that was underpinned by a reduced frequency of spike-specific memory B cells (MBCs). Improved neutralization breadth was seen against the Omicron variant (BA.1) after the third vaccine dose in PLWH but lower nAb responses persisted and were associated with global MBC dysfunction. In contrast, SARS-CoV-2 vaccination induced robust T cell responses that cross-recognized variants in PLWH. Strikingly, individuals with low or absent neutralization had detectable functional T cell responses. These PLWH had reduced numbers of circulating T follicular helper cells and an enriched population of CXCR3
Identifiants
pubmed: 36590902
doi: 10.1016/j.isci.2022.105862
pii: S2589-0042(22)02135-6
pmc: PMC9788849
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105862Subventions
Organisme : Medical Research Council
ID : MC_PC_20060
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W020556/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI155182
Pays : United States
Organisme : Medical Research Council
ID : MR/T032413/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R008698/1
Pays : United Kingdom
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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