Correlation of low fetal fraction of cell-free DNA at the early second-trimester and pregnancy complications related to placental dysfunction in twin pregnancy.
cell-free DNA
early screening
fetal fraction
pregnancy complications
twin pregnancy
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
08
2022
accepted:
15
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
3
1
2023
Statut:
epublish
Résumé
This study aimed to determine the correlation between fetal fraction (FF) of cell-free DNA (cf-DNA) and pregnancy complications related to placental dysfunction in Twin Pregnancy. This retrospective cohort study analyzed twin pregnant women who underwent non-invasive prenatal testing (NIPT) at 12 A total of 500 twin pregnancies (male-male twins, 245; female-female twins, 255) were included in this study. In LFF group (FF < 25th percentiles), maternal BMI was significantly higher than FF > 75th percentiles (23.6 kg/m LFF has a strong association with increased risk of SGA in twin pregnancy. Moreover, FF of cf-DNA may provide a new idea for the early screening of diseases related to placental dysfunction in twin pregnancy.
Identifiants
pubmed: 36590958
doi: 10.3389/fmed.2022.1011366
pmc: PMC9799160
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1011366Informations de copyright
Copyright © 2022 Li, Gu, Wei, Tao, Zhai, Peng, Huang, Deng and Yuan.
Déclaration de conflit d'intérêts
Authors CP, QH, and TD were employed by CapitalBio Technology Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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