Complement C3b contributes to
Escherichia coli
complement component C3
complement receptor 1
glycoprotein IIb/IIIa
multiplate aggregometry
platelet aggregation
thromboinflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
08
2022
accepted:
28
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
4
1
2023
Statut:
epublish
Résumé
Platelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis-associated coagulopathy. In this study, we investigated the role of complement in We found that compstatin, which inhibits the cleavage of complement component C3 to its components C3a and C3b, reduced the
Identifiants
pubmed: 36591264
doi: 10.3389/fimmu.2022.1020712
pmc: PMC9797026
doi:
Substances chimiques
Complement C3b
80295-43-8
Hirudins
0
Platelet Glycoprotein GPIIb-IIIa Complex
0
CR1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1020712Informations de copyright
Copyright © 2022 Landsem, Emblem, Lau, Christiansen, Gerogianni, Karlsen, Mollnes, Nilsson and Brekke.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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