The BNT162b2 vaccine induces humoral and cellular immune memory to SARS-CoV-2 Wuhan strain and the Omicron variant in children 5 to 11 years of age.
Omicron
SARS-CoV-2
antibodies
antigen-specific T cells
children
immune memory
memory B cells
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
11
2022
accepted:
29
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
4
1
2023
Statut:
epublish
Résumé
SARS-CoV-2 mRNA vaccines prevent severe COVID-19 by generating immune memory, comprising specific antibodies and memory B and T cells. Although children are at low risk of severe COVID-19, the spreading of highly transmissible variants has led to increasing in COVID-19 cases and hospitalizations also in the youngest, but vaccine coverage remains low. Immunogenicity to mRNA vaccines has not been extensively studied in children 5 to 11 years old. In particular, cellular immunity to the wild-type strain (Wuhan) and the cross-reactive response to the Omicron variant of concern has not been investigated. We assessed the humoral and cellular immune response to the SARS-CoV-2 BNT162b2 vaccine in 27 healthy children. We demonstrated that vaccination induced a potent humoral and cellular immune response in all vaccinees. By using spike-specific memory B cells as a measurable imprint of a previous infection, we found that 50% of the children had signs of a past, undiagnosed infection before vaccination. Children with pre-existent immune memory generated significantly increased levels of specific antibodies, and memory T and B cells, directed against not only the wild type virus but also the omicron variant.
Identifiants
pubmed: 36591287
doi: 10.3389/fimmu.2022.1094727
pmc: PMC9797965
doi:
Substances chimiques
BNT162 Vaccine
0
Vaccines
0
mRNA Vaccines
0
Antibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1094727Informations de copyright
Copyright © 2022 Cinicola, Piano Mortari, Zicari, Agrati, Bordoni, Albano, Fedele, Schiavoni, Leone, Fiore, Capponi, Conti, Petrarca, Stefanelli, Spalice, Midulla, Palamara, Quinti, Locatelli and Carsetti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Science. 2021 Dec 03;374(6572):abm0829
pubmed: 34648302
N Engl J Med. 2021 Jul 15;385(3):239-250
pubmed: 34043894
N Engl J Med. 2022 Sep 22;387(12):1141-1143
pubmed: 36069811
Cell Host Microbe. 2022 Mar 9;30(3):400-408.e4
pubmed: 35134333
J Int Med Res. 2022 May;50(5):3000605221102079
pubmed: 35619217
Curr Allergy Asthma Rep. 2022 May;22(5):53-60
pubmed: 35314921
Vaccine. 2022 Jun 9;40(26):3516-3527
pubmed: 35595662
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
Front Immunol. 2021 Nov 26;12:793953
pubmed: 34899762
Lancet. 2022 Jul 9;400(10346):97-103
pubmed: 35780801
N Engl J Med. 2022 May 19;386(20):1899-1909
pubmed: 35353976
Vaccines (Basel). 2022 Jul 08;10(7):
pubmed: 35891264
Sci Immunol. 2021 Dec 24;6(66):eabl5344
pubmed: 34726470
JAMA. 2022 Jun 14;327(22):2210-2219
pubmed: 35560036
Nat Immunol. 2019 Jan;20(1):97-108
pubmed: 30510223
Eur Child Adolesc Psychiatry. 2022 Jan;31(1):161-176
pubmed: 33205284
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Cell. 2022 Mar 17;185(6):1041-1051.e6
pubmed: 35202566
N Engl J Med. 2022 May 26;386(21):2011-2023
pubmed: 35544369
Immunity. 2022 Jun 14;55(6):1096-1104.e4
pubmed: 35483354
Nat Med. 2022 Mar;28(3):496-503
pubmed: 35090165
Mucosal Immunol. 2022 Apr;15(4):584-594
pubmed: 35505121
N Engl J Med. 2022 Aug 11;387(6):525-532
pubmed: 35857701
N Engl J Med. 2022 Oct 6;387(14):1333-1336
pubmed: 36103621
Ital J Pediatr. 2022 Mar 5;48(1):40
pubmed: 35248142
Int J Infect Dis. 2022 Mar;116:38-42
pubmed: 34971823
Cells. 2021 Sep 26;10(10):
pubmed: 34685521
Cell. 2022 Mar 3;185(5):847-859.e11
pubmed: 35139340
Nat Rev Immunol. 2022 Oct;22(10):591-592
pubmed: 35945353
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
N Engl J Med. 2022 Jan 6;386(1):35-46
pubmed: 34752019
Cell. 2022 Feb 3;185(3):457-466.e4
pubmed: 34995482
Lancet Child Adolesc Health. 2022 May;6(5):280-281
pubmed: 35189084
Nat Rev Immunol. 2021 Feb;21(2):83-100
pubmed: 33353987
MMWR Morb Mortal Wkly Rep. 2022 Aug 19;71(33):1047-1051
pubmed: 35980875
Nature. 2022 Feb;602(7896):183
pubmed: 35136225
Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676):
pubmed: 26194761
Acta Paediatr. 2021 Jul;110(7):2208-2211
pubmed: 33835507
JAMA Pediatr. 2022 Nov 1;176(11):1075-1076
pubmed: 36036928
JAMA. 2022 Jun 14;327(22):2242-2244
pubmed: 35559959
N Engl J Med. 2021 Dec 9;385(24):2241-2251
pubmed: 34379915
JAMA Pediatr. 2022 Aug 1;176(8):821-823
pubmed: 35675054
Sci Immunol. 2022 Jul 29;7(73):eabq3511
pubmed: 35549299
Cell Rep Med. 2022 Mar 29;3(4):100603
pubmed: 35480625
Sci Immunol. 2021 Apr 15;6(58):
pubmed: 33858945
Clin Infect Dis. 2022 Aug 24;75(1):e361-e367
pubmed: 35404391
N Engl J Med. 2021 Sep 2;385(10):954-956
pubmed: 34289272
Vaccines (Basel). 2022 Jun 30;10(7):
pubmed: 35891219
Cell. 2022 Feb 17;185(4):603-613.e15
pubmed: 35026152
Cell. 2022 May 26;185(11):1875-1887.e8
pubmed: 35523182