Exploring
CelTOS
N-glycosylation
Plasmodium falciparum
lipid nanoparticles
mRNA
malaria
malaria vaccine
nucleoside modifications
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
08
2022
accepted:
18
11
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
4
1
2023
Statut:
epublish
Résumé
The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites (CelTOS), is highly conserved among
Identifiants
pubmed: 36591298
doi: 10.3389/fimmu.2022.1026052
pmc: PMC9798330
doi:
Substances chimiques
Protozoan Proteins
0
Antigens, Protozoan
0
Recombinant Proteins
0
Antibodies, Protozoan
0
Cytokines
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1026052Informations de copyright
Copyright © 2022 Waghela, Mallory, Taylor, Schneider, Savransky, Janse, Lin, Tam, Weissman and Angov.
Déclaration de conflit d'intérêts
Authors IW and KM were employed by Parsons Corporation. PL and YT are employees of Acuitas Therapeutics Inc., a company focused on the development of lipid nanoparticulate nucleic acid delivery systems for therapeutic applications. YT is named on patents describing the use of modified mRNA lipid nanoparticles. In accordance with the University of Pennsylvania policies and procedures and our ethical obligations as researchers, we report that DW is named on patents that describe the use of nucleoside-modified mRNA as a platform to deliver therapeutic proteins and vaccines. We have disclosed those interests fully to the University of Pennsylvania, and we have in place an approved plan for managing any potential conflicts arising from licensing of our patents. The remaining authors declare that the research was conducted in the absences of any commercial or financial relationships that could be construed as a potential conflict of interest.
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