Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports.

anaplastic astrocytoma glioblastoma high-grade glioma prolonged survival wound infection

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2022
Historique:
received: 18 10 2022
accepted: 01 12 2022
entrez: 2 1 2023
pubmed: 3 1 2023
medline: 3 1 2023
Statut: epublish

Résumé

High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.

Identifiants

pubmed: 36591464
doi: 10.3389/fonc.2022.1073036
pmc: PMC9800515
doi:

Types de publication

Case Reports

Langues

eng

Pagination

1073036

Informations de copyright

Copyright © 2022 Solár, Mackerle, Hendrych, Pospisil, Lakomy, Valekova, Hermanova and Jancalek.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Peter Solár (P)

Department of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czechia.
Department of Neurosurgery, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Zdenek Mackerle (Z)

Department of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czechia.
Department of Neurosurgery, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Michal Hendrych (M)

First Department of Pathology, St. Anne's University Hospital Brno, Brno, Czechia.
First Department of Pathology, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Petr Pospisil (P)

Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, Brno, Czechia.

Radek Lakomy (R)

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Faculty of Medicine, Masaryk University, Brno, Czechia.

Hana Valekova (H)

Department of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czechia.
Department of Neurosurgery, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Marketa Hermanova (M)

First Department of Pathology, St. Anne's University Hospital Brno, Brno, Czechia.
First Department of Pathology, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Radim Jancalek (R)

Department of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czechia.
Department of Neurosurgery, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Classifications MeSH