Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States.
HIV
HIV-exposed uninfected
immune activation
inflammation
pediatrics
pregnancy
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
01 03 2023
01 03 2023
Historique:
received:
18
08
2022
accepted:
31
12
2022
pmc-release:
02
01
2024
pubmed:
3
1
2023
medline:
4
3
2023
entrez:
2
1
2023
Statut:
ppublish
Résumé
Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU). Using data from the Pediatric HIV/AIDS Cohort Study and an HIV-seronegative comparison group, we assessed associations of (1) HIV status, mode of HIV acquisition (perinatally vs nonperinatally acquired), and type of antiretroviral therapy (ART) with inflammation/immune activation in pregnancy; and (2) inflammation/immune activation in pregnancy with growth of CHEU at 12 months. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble(s) TNF-α receptor 1 and 2 (sTNFR1, sTNFR2), sCD14, and sCD163 were measured between 13 and 27 weeks' gestation. Linear regression models were fit to estimate differences between groups for each log-transformed biomarker, adjusted for confounders. Pregnant PWH (188 total, 39 perinatally acquired, 149 nonperinatally acquired) and 76 HIV-seronegative persons were included. PWH had higher IL-6, sTNFR1, sCD14, and sCD163 and lower sTNFR2 compared to HIV-seronegative persons in adjusted models. Among PWH, sCD163 was higher in those with perinatally versus nonperinatally acquired HIV and on PI-based versus INSTI-based ART. Higher maternal concentrations of IL-6, sTNFR2, and hs-CRP were associated with poorer growth at 12 months. Maternal HIV status is associated with a distinct profile of inflammation/immune activation during pregnancy, which may influence child growth.
Sections du résumé
BACKGROUND
Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU).
METHODS
Using data from the Pediatric HIV/AIDS Cohort Study and an HIV-seronegative comparison group, we assessed associations of (1) HIV status, mode of HIV acquisition (perinatally vs nonperinatally acquired), and type of antiretroviral therapy (ART) with inflammation/immune activation in pregnancy; and (2) inflammation/immune activation in pregnancy with growth of CHEU at 12 months. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble(s) TNF-α receptor 1 and 2 (sTNFR1, sTNFR2), sCD14, and sCD163 were measured between 13 and 27 weeks' gestation. Linear regression models were fit to estimate differences between groups for each log-transformed biomarker, adjusted for confounders.
RESULTS
Pregnant PWH (188 total, 39 perinatally acquired, 149 nonperinatally acquired) and 76 HIV-seronegative persons were included. PWH had higher IL-6, sTNFR1, sCD14, and sCD163 and lower sTNFR2 compared to HIV-seronegative persons in adjusted models. Among PWH, sCD163 was higher in those with perinatally versus nonperinatally acquired HIV and on PI-based versus INSTI-based ART. Higher maternal concentrations of IL-6, sTNFR2, and hs-CRP were associated with poorer growth at 12 months.
CONCLUSIONS
Maternal HIV status is associated with a distinct profile of inflammation/immune activation during pregnancy, which may influence child growth.
Identifiants
pubmed: 36592383
pii: 6967108
doi: 10.1093/infdis/jiac501
pmc: PMC10152501
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Interleukin-6
0
Lipopolysaccharide Receptors
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
720-730Subventions
Organisme : NIAAA NIH HHS
Pays : United States
Organisme : NIMH NIH HHS
Pays : United States
Organisme : NINDS NIH HHS
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA053157
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD103133
Pays : United States
Organisme : NIAID NIH HHS
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD104558
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD070760
Pays : United States
Organisme : NHLBI NIH HHS
Pays : United States
Organisme : NIDCD NIH HHS
Pays : United States
Organisme : NIDCR NIH HHS
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : NCI NIH HHS
Pays : United States
Investigateurs
Ellen Chadwick
(E)
Margaret Ann Sanders
(MA)
Kathleen Malee
(K)
Mary Paul
(M)
Ruth Eser-Jose
(R)
Chivon McMullen-Jackson
(C)
Lynnette Harris
(L)
Murli Purswani
(M)
Mahoobullah Mirza Baig
(MM)
Alma Villegas
(A)
Marvin Alvarado
(M)
Lisa-Gaye Robinson
(LG)
Jawara Dia Cooley
(JD)
James Blood
(J)
Patricia Garvie
(P)
William Borkowsky
(W)
Nagamah Sandra Deygoo
(NS)
Jennifer Lewis
(J)
Arry Dieudonne
(A)
Linda Bettica
(L)
Juliette Johnson
(J)
Karen Surowiec
(K)
Katherine Knapp
(K)
Jamie Russell-Bell
(J)
Megan Wilkins
(M)
Stephanie Love
(S)
Nicolas Rosario
(N)
Lourdes Angeli-Nieves
(L)
Vivian Olivera
(V)
Stephan Kohlhoff
(S)
Ava Dennie
(A)
Jean Kaye
(J)
Jenny Wallier
(J)
Karen Craig
(K)
Margarita Silio
(M)
Patricia Sirois
(P)
Cecelia Hutto
(C)
Paige Hickman
(P)
Julie Huldtquist
(J)
Dan Marullo
(D)
Stephen A Spector
(SA)
Veronica Figueroa
(V)
Megan Loughran
(M)
Sharon Nichols
(S)
Elizabeth McFarland
(E)
Christine Kwon
(C)
Carrie Glenny
(C)
Jennifer Englund
(J)
Mobeen Rathore
(M)
Saniyyah Mahmoudi
(S)
Sarah El-Hassan
(S)
Jamilah Tejan
(J)
Karen Hayani
(K)
Lourdes Richardson
(L)
Renee Smith
(R)
Alina Miller
(A)
Gwendolyn Scott
(G)
Gustavo Gil Garcia
(GG)
Gabriel Fernandez
(G)
Anai Cuadra
(A)
Toni Frederick
(T)
Mariam Davtyan
(M)
Guadalupe Morales-Avendano
(G)
Zoe M Rodriguez
(ZM)
Lizmarie Torres
(L)
Nydia Scalley
(N)
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Déclaration de conflit d'intérêts
Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Références
AIDS. 2016 Sep 24;30(15):2351-60
pubmed: 27456985
Pediatr Infect Dis J. 2017 Feb;36(2):189-197
pubmed: 27798548
Pediatr Infect Dis J. 2014 Jul;33(7):734-40
pubmed: 24378947
JAMA Netw Open. 2021 Dec 1;4(12):e2140584
pubmed: 34935918
Front Immunol. 2016 May 06;7:164
pubmed: 27199989
Semin Reprod Med. 2007 Jan;25(1):21-39
pubmed: 17205421
Clin Infect Dis. 2020 Jul 11;71(2):332-339
pubmed: 31504291
PLoS One. 2014 Dec 02;9(12):e114142
pubmed: 25462535
Pediatr Infect Dis J. 2019 May;38(5):500-502
pubmed: 30461574
HIV Med. 2021 Sep;22(8):674-681
pubmed: 34288357
J Infect Dis. 2009 Oct 15;200(8):1212-5
pubmed: 19728788
J Neuroinflammation. 2008 Oct 17;5:45
pubmed: 18925972
Nat Med. 2006 Dec;12(12):1365-71
pubmed: 17115046
AIDS. 2016 Jan;30(2):211-20
pubmed: 26684818
Curr HIV/AIDS Rep. 2017 Jun;14(3):93-100
pubmed: 28434169
Mucosal Immunol. 2012 Nov;5(6):646-57
pubmed: 22643849
Clin Infect Dis. 2015 Aug 15;61(4):651-60
pubmed: 25904376
J Trop Pediatr. 2019 Aug 1;65(4):373-379
pubmed: 30321432
J Infect Dis. 2016 Feb 1;213(3):343-50
pubmed: 26265778
J Infect Dis. 2011 Mar 15;203(6):780-90
pubmed: 21252259
Front Immunol. 2018 Apr 19;9:784
pubmed: 29725328
Lancet Glob Health. 2020 Jan;8(1):e67-e75
pubmed: 31791800
Lancet Child Adolesc Health. 2019 Apr;3(4):201-203
pubmed: 30773460
Front Immunol. 2016 May 23;7:199
pubmed: 27242802
Curr Dev Nutr. 2021 Sep 07;5(10):nzab113
pubmed: 34693193
Adv Data. 2000 Jun 8;(314):1-27
pubmed: 11183293
AIDS. 2019 Sep 1;33(11):1705-1710
pubmed: 31149945
Pediatr Res. 2022 Jul;92(1):233-241
pubmed: 34446848
HIV Res Clin Pract. 2019 Sep 3;:1-7
pubmed: 31478469
AIDS Care. 2018 Sep;30(9):1168-1172
pubmed: 29776314
J Infect Dis. 2011 May 15;203(10):1474-83
pubmed: 21502083
J Infect Dis. 2010 Jun 15;201(12):1788-95
pubmed: 20446848
Semin Immunol. 2008 Jun;20(3):181-6
pubmed: 18595731
AIDS. 2021 Nov 15;35(14):2289-2298
pubmed: 34224441
Open Forum Infect Dis. 2017 Aug 30;4(4):ofx187
pubmed: 29062860
Am J Epidemiol. 2012 May 1;175(9):950-61
pubmed: 22491086
PLoS One. 2011;6(5):e19968
pubmed: 21625498
Am J Obstet Gynecol. 2018 Feb;218(2S):S630-S640
pubmed: 29422205
Trop Med Int Health. 2017 Jan;22(1):52-62
pubmed: 27761979
J Infect Dis. 2015 Aug 1;212(3):345-54
pubmed: 25583168
AIDS. 2015 Jun 19;29(10):1263-5
pubmed: 26035325
Nat Neurosci. 2001 Nov;4(11):1116-22
pubmed: 11600888
J Reprod Immunol. 2020 Feb;137:102623
pubmed: 31710980
PLoS One. 2012;7(9):e45733
pubmed: 23029209
Immunity. 2013 Oct 17;39(4):633-45
pubmed: 24138880
Clin Infect Dis. 2018 Sep 14;67(7):1103-1109
pubmed: 29590318
Open Forum Infect Dis. 2021 May 17;8(6):ofab245
pubmed: 34159218
Lancet. 2015 Jun 27;385(9987):2606-15
pubmed: 25890673