Pigment epithelial detachment composition indices (PEDCI) in neovascular age-related macular degeneration.
Humans
Angiogenesis Inhibitors
/ therapeutic use
Retrospective Studies
Reproducibility of Results
Retinal Pigment Epithelium
/ diagnostic imaging
Tomography, Optical Coherence
/ methods
Visual Acuity
Intravitreal Injections
Retinal Detachment
/ diagnostic imaging
Macular Degeneration
/ diagnostic imaging
Wet Macular Degeneration
/ drug therapy
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 01 2023
02 01 2023
Historique:
received:
30
05
2022
accepted:
26
12
2022
entrez:
2
1
2023
pubmed:
3
1
2023
medline:
5
1
2023
Statut:
epublish
Résumé
We provide an automated analysis of the pigment epithelial detachments (PEDs) in neovascular age-related macular degeneration (nAMD) and estimate areas of serous, neovascular, and fibrous tissues within PEDs. A retrospective analysis of high-definition spectral-domain OCT B-scans from 43 eyes of 37 patients with nAMD with presence of fibrovascular PED was done. PEDs were manually segmented and then filtered using 2D kernels to classify pixels within the PED as serous, neovascular, or fibrous. A set of PED composition indices were calculated on a per-image basis using relative PED area of serous (PEDCI-S), neovascular (PEDCI-N), and fibrous (PEDCI-F) tissue. Accuracy of segmentation and classification within the PED were graded in masked fashion. Mean overall intra-observer repeatability and inter-observer reproducibility were 0.86 ± 0.07 and 0.86 ± 0.03 respectively using intraclass correlations. The mean graded scores were 96.99 ± 8.18, 92.12 ± 7.97, 91.48 ± 8.93, and 92.29 ± 8.97 for segmentation, serous, neovascular, and fibrous respectively. Mean (range) PEDCI-S, PEDCI-N, and PEDCI-F were 0.253 (0-0.952), 0.554 (0-1), and 0.193 (0-0.693). A kernel-based image processing approach demonstrates potential for approximating PED composition. Evaluating follow up changes during nAMD treatment with respect to PEDCI would be useful for further clinical applications.
Identifiants
pubmed: 36593323
doi: 10.1038/s41598-022-27078-x
pii: 10.1038/s41598-022-27078-x
pmc: PMC9807558
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
68Informations de copyright
© 2023. The Author(s).
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