Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children.
live-attenuated
parainfluenza
vaccine
Journal
Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049
Informations de publication
Date de publication:
18 Apr 2023
18 Apr 2023
Historique:
received:
27
08
2022
accepted:
02
01
2023
pmc-release:
03
01
2024
medline:
20
4
2023
pubmed:
4
1
2023
entrez:
3
1
2023
Statut:
ppublish
Résumé
We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.
Identifiants
pubmed: 36594442
pii: 6967372
doi: 10.1093/jpids/piac137
pmc: PMC10112673
doi:
Substances chimiques
Antibodies, Viral
0
Vaccines, Attenuated
0
Vaccines, Synthetic
0
Types de publication
Clinical Trial, Phase I
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-176Subventions
Organisme : NIAID NIH HHS
ID : HHS 272200900010C
Pays : United States
Informations de copyright
Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2023.
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