Nonquantal transmission at the vestibular hair cell-calyx synapse: K
computational neuroscience
ephaptic transmission
hair cells
synapse
vestibular
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 01 2023
10 01 2023
Historique:
entrez:
3
1
2023
pubmed:
4
1
2023
medline:
6
1
2023
Statut:
ppublish
Résumé
Vestibular hair cells transmit information about head position and motion across synapses to primary afferent neurons. At some of these synapses, the afferent neuron envelopes the hair cell, forming an enlarged synaptic terminal called a calyx. The vestibular hair cell-calyx synapse supports a mysterious form of electrical transmission that does not involve gap junctions, termed nonquantal transmission (NQT). The NQT mechanism is thought to involve the flow of ions from the presynaptic hair cell to the postsynaptic calyx through low-voltage-activated channels driven by changes in cleft [K
Identifiants
pubmed: 36595693
doi: 10.1073/pnas.2207466120
pmc: PMC9926171
doi:
Substances chimiques
Potassium Chloride
660YQ98I10
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2207466120Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC002290
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC012347
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
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