Effect of Leishmania RNA virus 2 on virulence factors and cytokines gene expression in a human macrophage infected with Leishmania major: A preliminary study.
Cytokines
Gene expression
In vitro
Leishmania RNA virus 2
THP-1 monocytes
Journal
Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
31
10
2022
accepted:
30
12
2022
pubmed:
4
1
2023
medline:
25
2
2023
entrez:
3
1
2023
Statut:
ppublish
Résumé
Cutaneous leishmaniasis (CL) is one of the most important infectious parasitic diseases in the world caused by the Leishmania parasite. In recent decades, the presence of a virus from the Totiviridae family has been proven in some Leishmania species. Although the existence of LRV2 in the Old world Leishmania species has been confirmed, almost no studies have been done to determine the potential impact of LRV2 on the immunopathogenicity of the Leishmania parasite. In this preliminary study, we measured the expression of target genes, including Glycoprotein 63 (gp63), Heat Shock Protein 70 (hsp70), Cysteine Protease b (cpb), Interleukin 1 beta (IL-1β), IL8 and IL-12 in LRV2 positive Leishmania major strain (LRV2
Identifiants
pubmed: 36596336
pii: S0014-4894(22)00253-3
doi: 10.1016/j.exppara.2022.108459
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-12
187348-17-0
Virulence Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108459Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that there is no conflict of interests.