Circovirus Hepatitis Infection in Heart-Lung Transplant Patient, France.
France
circoviruses
hepatitis
mNGS
metagenomic next-generation sequencing
solid organ transplants
viruses
zoonoses
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
pubmed:
4
1
2023
medline:
25
1
2023
entrez:
3
1
2023
Statut:
ppublish
Résumé
In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. After ruling out common etiologies, we used metagenomic next-generation sequencing to analyze a liver biopsy sample and identified an unknown species of circovirus, tentatively named human circovirus 1 (HCirV-1). We found no other viral or bacterial sequences. HCirV-1 shared 70% amino acid identity with the closest known viral sequences. The viral genome was undetectable in blood samples from 2017-2019, then became detectable at low levels in September 2020 and peaked at very high titers (10
Identifiants
pubmed: 36596569
doi: 10.3201/eid2902.221468
pmc: PMC9881760
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
286-293Références
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