Distribution of Vernix Caseosa and Associated Factors Among Newborns Delivered at Adama Comprehensive Specialized Hospital Medical College, Ethiopia, in 2022: Cross-Sectional Study.
epidermal barrier
stratum corneum
vernix caseosa
Journal
Clinical, cosmetic and investigational dermatology
ISSN: 1178-7015
Titre abrégé: Clin Cosmet Investig Dermatol
Pays: New Zealand
ID NLM: 101543449
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
09
2022
accepted:
09
12
2022
entrez:
4
1
2023
pubmed:
5
1
2023
medline:
5
1
2023
Statut:
epublish
Résumé
Vernix caseosa is a complex proteolipid material synthesized partly by fetal sebaceous glands during the last trimester of pregnancy. Understanding the structure and function of newborn skin is crucial for determining optimal thermal support, infection control, and skin moisturization. So far, in Ethiopia, there is no research done related to the distribution of vernix caseosa and associated factors on newborn skin. Doing such research could give awareness about factors associated with the distribution of vernix caseosa on newborns' skin and to take necessary protective measures for those that may be affected. The objective of this study is to assess the distribution of vernix caseosa and associated factors among newborns delivered at Adama Comprehensive Specialized Hospital Medical College from November to December 1, 2021. Hospital-based cross-sectional study design was conducted from November to December 1, 2021 at Adama Comprehensive Specialized Hospital Medical College (ACSHMC). Four hundred twenty-two eligible newborns were selected by a systematic sampling method. Data were collected by four data collectors by using a pretested questionnaire. The distribution of vernix caseosa on the different regions of the neonate was assessed, by exposing their whole body for a minute. Data entry was done by EPI data version 4.6 and analyzed by using SPSS version 25. A logistic regression of P-value of <0.25 during bivariate and P < 0.05 during multivariate analysis at a 95% confidence level was considered statistically significant. Out of 422 study participants 231 (54.7%) with 95% CI (49.8, 59.8) babies had vernix caseosa. Being primiparous with (AOR = 1.9, PV = 0.013, 95% CI: 1.141, 2.92), being multiparous with (AOR = 1.98, PV = 0.04, CI: 1.29, 3.225), being females with (AOR = 2.1, PV = 0.001, CI: 1.39, 3.18), being preterm with (AOR = 2.98, PV = 0.036, 95% CI: 1.08, 10.72), non-diseased newborns with (AOR = 1.6, PV = 0.046, 95% CI: 1.07, 2.7) were identified as associated factors for the distribution of vernix caseosa on the newborn skin. This study showed that the distribution of vernix caseosa on the skin of the newborns was associated with parity, sex, gestational age, and absence of disease.
Sections du résumé
Background
UNASSIGNED
Vernix caseosa is a complex proteolipid material synthesized partly by fetal sebaceous glands during the last trimester of pregnancy. Understanding the structure and function of newborn skin is crucial for determining optimal thermal support, infection control, and skin moisturization. So far, in Ethiopia, there is no research done related to the distribution of vernix caseosa and associated factors on newborn skin. Doing such research could give awareness about factors associated with the distribution of vernix caseosa on newborns' skin and to take necessary protective measures for those that may be affected.
Objective
UNASSIGNED
The objective of this study is to assess the distribution of vernix caseosa and associated factors among newborns delivered at Adama Comprehensive Specialized Hospital Medical College from November to December 1, 2021.
Methodology
UNASSIGNED
Hospital-based cross-sectional study design was conducted from November to December 1, 2021 at Adama Comprehensive Specialized Hospital Medical College (ACSHMC). Four hundred twenty-two eligible newborns were selected by a systematic sampling method. Data were collected by four data collectors by using a pretested questionnaire. The distribution of vernix caseosa on the different regions of the neonate was assessed, by exposing their whole body for a minute. Data entry was done by EPI data version 4.6 and analyzed by using SPSS version 25. A logistic regression of P-value of <0.25 during bivariate and P < 0.05 during multivariate analysis at a 95% confidence level was considered statistically significant.
Results
UNASSIGNED
Out of 422 study participants 231 (54.7%) with 95% CI (49.8, 59.8) babies had vernix caseosa. Being primiparous with (AOR = 1.9, PV = 0.013, 95% CI: 1.141, 2.92), being multiparous with (AOR = 1.98, PV = 0.04, CI: 1.29, 3.225), being females with (AOR = 2.1, PV = 0.001, CI: 1.39, 3.18), being preterm with (AOR = 2.98, PV = 0.036, 95% CI: 1.08, 10.72), non-diseased newborns with (AOR = 1.6, PV = 0.046, 95% CI: 1.07, 2.7) were identified as associated factors for the distribution of vernix caseosa on the newborn skin.
Conclusion
UNASSIGNED
This study showed that the distribution of vernix caseosa on the skin of the newborns was associated with parity, sex, gestational age, and absence of disease.
Identifiants
pubmed: 36597521
doi: 10.2147/CCID.S387720
pii: 387720
pmc: PMC9805746
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2903-2914Informations de copyright
© 2022 Mesfin et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in this work.
Références
ISRN Dermatol. 2014 Jan 20;2014:360590
pubmed: 24575304
Clin Dermatol. 2015 May-Jun;33(3):271-80
pubmed: 25889127
Rev Paul Pediatr. 2019 Jun 03;37(3):297-304
pubmed: 31166467
Actas Dermosifiliogr. 2011 Nov;102(9):726-9
pubmed: 21481821
Br J Dermatol. 2002 Feb;146(2):194-201
pubmed: 11903227
Neonatal Netw. 2015;34(4):216-9
pubmed: 26802635
Case Rep Gastroenterol. 2012 Jan;6(1):217-22
pubmed: 22701398
Exp Mol Med. 1999 Mar 31;31(1):5-19
pubmed: 10231017
Indian J Dermatol. 2008;53(2):54-60
pubmed: 19881987
Soc Sci Med. 2005 Mar;60(5):911-21
pubmed: 15589663
Physiol Meas. 2018 Nov 01;39(10):105013
pubmed: 30235166
J Pediatr. 2017 Dec;191:262-265.e2
pubmed: 29173315
J Perinatol. 2005 Jul;25(7):440-6
pubmed: 15830002
South Med J. 1995 Oct;88(10):1031-3
pubmed: 7481958
Ann Dermatol. 2013 Feb;25(1):1-4
pubmed: 23467501
Cell Mol Life Sci. 2005 Oct;62(19-20):2390-9
pubmed: 16179970
Anal Bioanal Chem. 2020 Apr;412(10):2291-2302
pubmed: 31907593
Int J Mol Sci. 2013 May 24;14(6):10869-95
pubmed: 23708093
J Clin Invest. 1996 Jun 1;97(11):2576-84
pubmed: 8647951
PLoS One. 2014 Jun 09;9(6):e99173
pubmed: 24911066
J Invest Dermatol. 2000 Nov;115(5):875-81
pubmed: 11069626
J Clin Diagn Res. 2015 Nov;9(11):SC13-6
pubmed: 26674069
J Cosmet Sci. 2007 Nov-Dec;58(6):651-62
pubmed: 18305878
AACN Clin Issues. 2003 Nov;14(4):457-64
pubmed: 14595204
Br J Dermatol. 2002 Dec;147(6):1127-34
pubmed: 12452861