Applicability of the Edinburgh CT Criteria for Lobar Intracerebral Hemorrhage Associated with Cerebral Amyloid Angiopathy.
CT scan
Cerebral amyloid angiopathy
External validation of Edinburgh criteria
Lobar hemorrhage
Revised Boston criteria
Journal
Clinical neuroradiology
ISSN: 1869-1447
Titre abrégé: Clin Neuroradiol
Pays: Germany
ID NLM: 101526693
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
10
06
2022
accepted:
11
10
2022
medline:
29
5
2023
pubmed:
5
1
2023
entrez:
4
1
2023
Statut:
ppublish
Résumé
Based on histopathology, Edinburgh diagnostic criteria were proposed to consider a nontraumatic intracerebral lobar hemorrhage (ICH) as related to cerebral amyloid angiopathy (CAA) using the initial computed tomography (CT) scan and the APOE genetic status. We aimed to externally validate the Edinburgh prediction model, excluding the APOE genotyping and based on the modified Boston criteria on the MRI for CAA diagnosis METHODS: We included patients admitted for spontaneous lobar ICH in the emergency department between 2016 and 2019 who underwent noncontrast CT scan and MRI. According to the MRI, patients were classified into the CAA group or into the non-CAA group in the case of other causes of ICH. Two neuroradiologists, blinded to the final retained diagnosis, rated each radiological feature on initial CT scan described in the Edinburgh study on initial CT scan RESULTS: A total of 102 patients were included, of whom 36 were classified in the CAA group, 46 in the non-CAA causes group and 20 of undetermined cause (excluded from the primary analysis). The Edinburgh prediction model, including finger-like projections and subarachnoid extension showed an area under receiver operating characteristic curves (AUC) of 0.760 (95% confidence interval, CI: 0.660-0.859) for the diagnosis of CAA. The AUC reached 0.808 (95% CI: 0.714-0.901) in a new prediction model integrating a third radiologic variable: the ICH cortical involvement. Using the Boston MRI criteria as a final assessment, we provided a new external confirmation of the radiological Edinburgh CT criteria, which are directly applicable in acute settings of spontaneous lobar ICH and further proposed an original 3‑set model considering finger-like projections, subarachnoid extension, and cortical involvement that may achieve a high discrimination performance.
Identifiants
pubmed: 36598532
doi: 10.1007/s00062-022-01230-6
pii: 10.1007/s00062-022-01230-6
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-465Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Références
Biffi A, Greenberg SM. Cerebral amyloid angiopathy: a systematic review. J Clin Neurol. 2011;7:1–9.
doi: 10.3988/jcn.2011.7.1.1
pubmed: 21519520
pmcid: 3079153
Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA. Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol. 2011;69:320–7.
doi: 10.1002/ana.22112
pubmed: 21387377
Haley KE, Greenberg SM, Gurol ME. Cerebral microbleeds and macrobleeds: should they influence our recommendations for antithrombotic therapies? Curr Cardiol Rep. 2013;15:425.
doi: 10.1007/s11886-013-0425-8
pubmed: 24122195
pmcid: 3965371
Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum. J Neurol Neurosurg Psychiatry. 2012;83:124–37.
doi: 10.1136/jnnp-2011-301308
pubmed: 22056963
Mehndiratta P, Manjila S, Ostergard T, Eisele S, Cohen ML, Sila C, Selman WR. Cerebral amyloid angiopathy-associated intracerebral hemorrhage: pathology and management. Neurosurg Focus. 2012;32:E7.
doi: 10.3171/2012.1.FOCUS11370
pubmed: 22463117
Bardutzky J, Hieber M, Roelz R, Meckel S, Lambeck J, Niesen WD. Cerebral amyloid angiopathy-related intracerebral hemorrhage: Feasibility and safety of bedside catheter hematoma evacuation with urokinase. Clin Neurol Neurosurg. 2020;190:105655.
doi: 10.1016/j.clineuro.2019.105655
pubmed: 31901893
Mendelow AD, Gregson BA, Rowan EN, Murray GD, Gholkar A, Mitchell PM. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet. 2013;382:397–408.
doi: 10.1016/S0140-6736(13)60986-1
pubmed: 23726393
pmcid: 3906609
Morgenstern LB, Frankowski RF, Shedden P, Pasteur W, Grotta JC. Surgical treatment for intracerebral hemorrhage (STICH): a single-center, randomized clinical trial. Neurology. 1998;51:1359–63.
doi: 10.1212/WNL.51.5.1359
pubmed: 9818860
Linn J, Halpin A, Demaerel P, Ruhland J, Giese AD, Dichgans M, van Buchem MA, Bruckmann H, Greenberg SM. Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology. 2010;74:1346–50.
doi: 10.1212/WNL.0b013e3181dad605
pubmed: 20421578
pmcid: 2875936
Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston Criteria. Neurology. 2001;56:537–9.
doi: 10.1212/WNL.56.4.537
pubmed: 11222803
Charidimou A, Jaunmuktane Z, Baron JC, Burnell M, Varlet P, Peeters A, Xuereb J, Jäger R, Brandner S, Werring DJ. White matter perivascular spaces: an MRI marker in pathology-proven cerebral amyloid angiopathy? Neurology. 2014;82:57–62.
doi: 10.1212/01.wnl.0000438225.02729.04
pubmed: 24285616
pmcid: 3873625
Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8:355–69.
doi: 10.1016/S1474-4422(09)70025-0
pubmed: 19233729
Rodrigues MA, Samarasekera N, Lerpiniere C, Humphreys C, McCarron MO, White PM, Nicoll JAR, Sudlow CLM, Cordonnier C, Wardlaw JM, Smith C, Al-Shahi SR. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. Lancet Neurol. 2018;17:232–40.
doi: 10.1016/S1474-4422(18)30006-1
pubmed: 29331631
pmcid: 5818029
van Etten ES, Kaushik K, van Zwet EW, Voigt S, van Walderveen MAA, van Buchem MA, Terwindt GM, Wermer MJH. Sensitivity of the Edinburgh criteria for lobar intracerebral hemorrhage in hereditary cerebral amyloid angiopathy. Stroke. 2020;51:3608–12.
doi: 10.1161/STROKEAHA.120.031264
pubmed: 33148142
Sembill JA, Knott M, Xu M, Roeder SS, Hagen M, Sprügel MI, Mrochen A, Borutta M, Hoelter P, Engelhorn T, Rothhammer V, Macha K, Kuramatsu JB. Simplified Edinburgh CT criteria for identification of lobar intracerebral hemorrhage associated with cerebral amyloid angiopathy. Neurology. 2022;98(20):e1997–2004.
pubmed: 35314501
Caetano A, Ladeira F, Barbosa R, Calado S, Viana-Baptista M. Cerebral amyloid angiopathy—The modified Boston criteria in clinical practice. J Neurol Sci. 2018;384:55–7.
doi: 10.1016/j.jns.2017.11.021
pubmed: 29249378
Schwarz G, Banerjee G, Hostettler IC, Ambler G, Seiffge DJ, Ozkan H, Browning S, Simister R, Wilson D, Cohen H, Yousry T, Salman RA, Lip GYH, Brown MM, Muir KW, Houlden H, Jäger R, Werring DJ. MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage. Int J Stroke. 2022. https://doi.org/10.1177/17474930211062478 . Epub ahead of print.
Fakan B, Reisz Z, Zadori D, Vecsei L, Klivenyi P, Szalardy L. Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy. J Neural Transm (Vienna). 2020;127:963–72. Erratum in: J Neural Transm (Vienna). 2020 May 9.
Meretoja A, Strbian D, Putaala J, Curtze S, Haapaniemi E, Mustanoja S, Sairanen T, Satopää J, Silvennoinen H, Niemelä M, Kaste M, Tatlisumak T. SMASH-U: a proposal for etiologic classification of Intracerebral hemorrhage. Stroke. 2012;43:2592–7.
doi: 10.1161/STROKEAHA.112.661603
pubmed: 22858729
Lange M, Feiden W. Amyloid angiopathy—a rare cause of intracerebral hemorrhage. Neurosurg Rev. 1991;14:297–301.
doi: 10.1007/BF00383267
pubmed: 1791945
Zhang Y, Wang X, Schultz C, Lanzino G, Rabinstein AA. Postoperative outcome of cerebral amyloid angiopathy-related lobar intracerebral hemorrhage: case series and systematic review. Neurosurgery. 2012;70:125–30. discussion 130.
doi: 10.1227/NEU.0b013e31822ea02a
pubmed: 21937942
Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease – one peptide, two pathways. Nat Rev Neurol. 2020;16:30–42.
Viguier A, Raposo N, Patsoura S, Calviere L, Albucher JF, Ruidavets JB, Chollet F, Cognard C, Olivot JM, Bonneville F. Subarachnoid and subdural hemorrhages in lobar Intracerebral hemorrhage associated with cerebral amyloid angiopathy. Stroke. 2019;50:1567–9.
doi: 10.1161/STROKEAHA.119.024837
pubmed: 31136281
Samarasekera N, Rodrigues MA, Toh PS, Al-Shahi R. Imaging features of intracerebral hemorrhage with cerebral amyloid angiopathy: Systematic review and meta-analysis. PLoS One. 2017;12:e0180923. Erratum in: PLoS One. 2017;12:e0187386.
doi: 10.1371/journal.pone.0180923
pubmed: 28700676
pmcid: 5507310
Andoh Y, Wakai S, Nagai M, Honma K, Fujihara S. [Lobar intracerebral hemorrhage secondary to cerebral amyloid angiopathy: a clinicopathologic study of three operated cases]. No To Shinkei. 1989;41:1217–23.
pubmed: 2697377
Miller JH, Wardlaw JM, Lammie GA. Intracerebral haemorrhage and cerebral amyloid angiopathy: CT features with pathological correlation. Clin Radiol. 1999;54:422–9.
doi: 10.1016/S0009-9260(99)90825-5
pubmed: 10437691
Wagle WA, Smith TW, Weiner M. Intracerebral hemorrhage caused by cerebral amyloid angiopathy: radiographic-pathologic correlation. AJNR Am J Neuroradiol. 1984;5:171–6.
pubmed: 6422718
pmcid: 8332534
Renard D, Parvu T, Thouvenot E. Finger-like projections in lobar haemorrhage on early magnetic resonance imaging is associated with probable cerebral amyloid angiopathy. Cerebrovasc Dis. 2019;47:121–6.
doi: 10.1159/000499032
pubmed: 31063997
Lang EW, Ren YaZ, Preul C, Hugo HH, Hempelmann RG, Buhl R, Barth H, Klinge H, Mehdorn HM. Stroke pattern interpretation: the variability of hypertensive versus amyloid angiopathy hemorrhage. Cerebrovasc Dis. 2001;12:121–30.
doi: 10.1159/000047691
pubmed: 11490106
Uniken Venema SM, Marini S, Brouwers HB, Morotti A, Woo D, Anderson CD, Rosand J. Associations of radiographic cerebral small vessel disease with acute intracerebral hemorrhage volume, hematoma expansion, and intraventricular hemorrhage. Neurocrit Care. 2020;32:383–91.
doi: 10.1007/s12028-019-00876-4
pubmed: 31845173
Zhang Y, Zhang B, Liang F, Liang S, Zhang Y, Yan P, Ma C, Liu A, Guo F, Jiang C. Radiomics features on non-contrast-enhanced CT scan can precisely classify AVM-related hematomas from other spontaneous intraparenchymal hematoma types. Eur Radiol. 2019;29:2157–65.
doi: 10.1007/s00330-018-5747-x
pubmed: 30306329
Ornello R, Colangeli E, Tommasino E, Tiseo C, Perrotta G, Scarpato C, Gentile M, Mammarella L, Marini C, Pistoia F, Splendiani A, Sacco S. Clinical usefulness of Edinburgh CT criteria in patients with lobar intracerebral hemorrhage. Eur Stroke J. 2021;6:36–43.
doi: 10.1177/2396987320975736
pubmed: 33817333