Increased cerebral vascular resistance underlies preserved cerebral blood flow in response to orthostasis in humans on a high-salt diet.
Blood pressure
Catecholamine
Cerebral autoregulation
Endothelium-dependent vasodilation
High salt intake
Middle cerebral artery
Orthostatic test
Transcranial Doppler ultrasound
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
29
08
2022
accepted:
20
12
2022
pubmed:
5
1
2023
medline:
24
3
2023
entrez:
4
1
2023
Statut:
ppublish
Résumé
Cerebral blood flow autoregulation protects brain tissue from blood pressure variations and maintains cerebral perfusion pressure by changes in vascular resistance. High salt (HS) diet impairs endothelium-dependent vasodilation in many vascular beds, including cerebral microcirculation, and may affect vascular resistance. The aim of present study was to determine if 7-day HS diet affected the reactivity of middle cerebral artery (MCA) to orthostatic challenge in healthy human individuals, and if autoregulatory mechanisms and sympathetic neural regulation were involved in this phenomenon.Twenty-seven persons participated in study (F:21, M:6, age range 19-24). Participants consumed 7-day low-salt (LS) diet (< 2.3 g kitchen salt/day) and afterwards 7-day HS diet (> 11.2 g kitchen salt/day). Blood and urine analysis and anthropometric measurements were performed after each diet. Arterial blood pressure, heart rate and heart rate variability, and cerebral and systemic hemodynamic parameters were recorded simultaneously with transcranial Doppler ultrasound and The Task Force® Monitor in response to orthostatic test.Participants remained normotensive during HS diet. Following both, the LS and HS dietary protocols, mean cerebral blood flow (CBF), as well as the velocity time integral and diastolic blood pressure decreased, and cerebral pulsatility index increased after rising up. Importantly, cerebrovascular resistance significantly increased in response to orthostasis only after HS diet. Urine concentration of noradrenaline and vanillylmandelic acid, baroreflex sensitivity (BRS), and sympathetic neural control was significantly decreased in HS diet.Results suggest that CBF in response to orthostatic test was preserved in HS condition due to altered vascular reactivity of MCA, with increased cerebrovascular resistance and blunted BRS and sympathetic activity.
Identifiants
pubmed: 36598577
doi: 10.1007/s00421-022-05124-w
pii: 10.1007/s00421-022-05124-w
doi:
Substances chimiques
Sodium Chloride, Dietary
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
923-933Subventions
Organisme : Sveučilište Josipa Jurja Strossmayera u Osijeku
ID : INGI 2015-16
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Ainslie PN, Brassard P. Why is the neural control of cerebral autoregulation so controversial? F1000Prime Rep 2014;6:14. https://doi.org/10.12703/P6-14 .
Allen LA, Schmidt JR, Thompson CT, Carlson BE, Beard DA, Lombard JH (2019) High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression. Microcirculation 26: https://doi.org/10.1111/micc.12518
doi: 10.1111/micc.12518
pubmed: 30481399
pmcid: 6465152
Babcock MC, Brian MS, Watso JC, Edwards DG, Stocker SD, Wenner MM et al (2018) Alterations in dietary sodium intake affect cardiovagal baroreflex sensitivity. Am J Physiol Regul Integr Comp Physiol 315:R688–R695. https://doi.org/10.1152/ajpregu.00002.2018
doi: 10.1152/ajpregu.00002.2018
pubmed: 29949407
pmcid: 6230891
Barić L, Drenjančević I, Matić A, Stupin M, Kolar L, Mihaljević Z et al (2019) Seven-day salt loading impairs microvascular endothelium-dependent vasodilation without changes in blood pressure, body composition and fluid status in healthy young humans. Kidney Blood Press Res 44:835–847. https://doi.org/10.1159/000501747
doi: 10.1159/000501747
pubmed: 31430746
Bragulat E, de la Sierra A (2002) Salt intake, endothelial dysfunction, and salt-sensitive hypertension. J Clin Hypertens (greenwich) 4:41–46. https://doi.org/10.1111/j.1524-6175.2002.00503.x
doi: 10.1111/j.1524-6175.2002.00503.x
pubmed: 11821636
Bragulat E, de la Sierra A, Antonio MT, Coca A (2001) Endothelial dysfunction in salt-sensitive essential hypertension. Hypertension 37:444–448. https://doi.org/10.1161/01.hyp.37.2.444
doi: 10.1161/01.hyp.37.2.444
pubmed: 11230316
Brittain JM, Busk TM, Møller S (2018) Validation of non-invasive haemodynamic methods in patients with liver disease: the finometer and the task force monitor. Clin Physiol Funct Imaging 38:384–389. https://doi.org/10.1111/cpf.12425
doi: 10.1111/cpf.12425
pubmed: 28402021
Čavka A, Ćosić A, Jukić I, Jelaković B, Lombard JH, Phillips SA et al (2015) The role of cyclo-oxygenase-1 in high-salt diet-induced microvascular dysfunction in humans. J Physiol (lond) 593:5313–5324. https://doi.org/10.1113/JP271631
doi: 10.1113/JP271631
pubmed: 26498129
Čavka A, Jukić I, Ali M, Goslawski M, Bian J-T, Wang E et al (2016) Short term high salt intake reduces brachial artery and microvascular function in the absence of changes in blood pressure. J Hypertens 34:676–684. https://doi.org/10.1097/HJH.0000000000000852
doi: 10.1097/HJH.0000000000000852
pubmed: 26848993
pmcid: 6711169
Drenjančević-Perić I, Weinberg BD, Greene AS, Lombard JH (2010) Restoration of cerebral vascular relaxation in renin congenic rats by introgression of the Dahl R renin gene. Am J Hypertens 23:243–248. https://doi.org/10.1038/ajh.2009.236
doi: 10.1038/ajh.2009.236
pubmed: 19959997
DuPont JJ, Greaney JL, Wenner MM, Lennon-Edwards SL, Sanders PW, Farquhar WB et al (2013) High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens 31:530–536. https://doi.org/10.1097/HJH.0b013e32835c6ca8
doi: 10.1097/HJH.0b013e32835c6ca8
pubmed: 23263240
pmcid: 4176919
Isogai O, Tsukamoto K, Masubuchi Y, Tomioka S, Suzuki T, Kawato H et al (2005) High salt diet enhances cardiovascular responses from the nucleus tractus solitarius and ventrolateral medulla of Sprague-Dawley rats. Clin Exp Hypertens 27:33–44. https://doi.org/10.1081/ceh-200044252
doi: 10.1081/ceh-200044252
pubmed: 15773228
Joyner MJ, Charkoudian N, Wallin BG (2008) A sympathetic view of the sympathetic nervous system and human blood pressure regulation. Exp Physiol 93:715–724. https://doi.org/10.1113/expphysiol.2007.039545
doi: 10.1113/expphysiol.2007.039545
pubmed: 18326553
pmcid: 3433836
Kozina N, Mihaljević Z, Lončar MB, Mihalj M, Mišir M, Radmilović MD, et al. Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice. Int J Mol Sci 2019;20. https://doi.org/10.3390/ijms20205188 .
ter Laan M, van Dijk JMC, Elting JWJ, Staal MJ, Absalom AR (2013) Sympathetic regulation of cerebral blood flow in humans: a review. Br J Anaesth 111:361–367. https://doi.org/10.1093/bja/aet122
doi: 10.1093/bja/aet122
pubmed: 23616589
Mahdi A, Olufsen M, Payne S. Mathematical model of the interaction between baroreflex and cerebral autoregulation 2015.
Mancia G, Grassi G (2014) The autonomic nervous system and hypertension. Circ Res 114:1804–1814. https://doi.org/10.1161/CIRCRESAHA.114.302524
doi: 10.1161/CIRCRESAHA.114.302524
pubmed: 24855203
Mancini M, Ferrara LA, Pisanti N, Fasano ML, Mancini M (1986) Effects of sodium intake on blood pressure and adrenergic vascular reactivity. J Clin Hypertens 2:315–321
pubmed: 3806148
McDonnell MN, Berry NM, Cutting MA, Keage HA, Buckley JD, Howe PRC (2013) Transcranial Doppler ultrasound to assess cerebrovascular reactivity: reliability, reproducibility and effect of posture. PeerJ 1:e65. https://doi.org/10.7717/peerj.65
doi: 10.7717/peerj.65
pubmed: 23646284
pmcid: 3642776
Migdal KU, Robinson AT, Watso JC, Babcock MC, Lennon SL, Martens CR et al (2021) Ten days of high dietary sodium does not impair cerebral blood flow regulation in healthy adults. Auton Neurosci 234:102826. https://doi.org/10.1016/j.autneu.2021.102826
doi: 10.1016/j.autneu.2021.102826
pubmed: 34058717
pmcid: 8315190
Cosic A, Jukic I, Stupin A, Mihalj M, Mihaljevic Z, Novak S et al (2016) Attenuated flow-induced dilatation of middle cerebral arteries is related to increased vascular oxidative stress in rats on a short-term high salt diet. J Physiol (Lond) 594:4917–4931. https://doi.org/10.1113/JP272297
doi: 10.1113/JP272297
pubmed: 27061200
Cipolla MJ, Liebeskind DS, Chan S-L (2018) The importance of comorbidities in ischemic stroke: impact of hypertension on the cerebral circulation. J Cereb Blood Flow Metab 38:2129–2149. https://doi.org/10.1177/0271678X18800589
doi: 10.1177/0271678X18800589
pubmed: 30198826
pmcid: 6282213
Munoz AC, Vohra S, Gupta M (2020) Orthostasis. StatPearls Publishing, StatPearls, Treasure Island (FL)
Nasr N, Czosnyka M, Pavy-Le Traon A, Custaud M-A, Liu X, Varsos GV et al (2014) Baroreflex and cerebral autoregulation are inversely correlated. Circ J 78:2460–2467. https://doi.org/10.1253/circj.CJ-14-0445
doi: 10.1253/circj.CJ-14-0445
pubmed: 25187067
Ogoh S, Brothers RM, Eubank WL, Raven PB (2008) Autonomic neural control of the cerebral vasculature: acute hypotension. Stroke 39:1979–1987. https://doi.org/10.1161/STROKEAHA.107.510008
doi: 10.1161/STROKEAHA.107.510008
pubmed: 18451346
Parati G, Bilo G (2012) Arterial baroreflex modulation of sympathetic activity and arterial wall properties: new evidence. Hypertension 59:5–7. https://doi.org/10.1161/HYPERTENSIONAHA.111.182766
doi: 10.1161/HYPERTENSIONAHA.111.182766
pubmed: 22106402
Ruppert M, Diehl J, Kolloch R, Overlack A, Kraft K, Göbel B et al (1991) Short-term dietary sodium restriction increases serum lipids and insulin in salt-sensitive and salt-resistant normotensive adults. Klin Wochenschr 69(Suppl 25):51–57
pubmed: 1921253
Sarkar S, Ghosh S, Ghosh SK, Collier A (2007) Role of transcranial Doppler ultrasonography in stroke. Postgrad Med J 83(985):683–689. https://doi.org/10.1136/pgmj.2007.058602
doi: 10.1136/pgmj.2007.058602
pubmed: 17989267
pmcid: 2659960
Shimoura CG, Lincevicius GS, Nishi EE, Girardi ACC, Simon KA, Bergamaschi CT et al (2017) Increased dietary salt changes baroreceptor sensitivity and intrarenal renin-angiotensin system in goldblatt hypertension. Am J Hypertens 30:28–36. https://doi.org/10.1093/ajh/hpw107
doi: 10.1093/ajh/hpw107
pubmed: 27629265
Strazzullo P, D’Elia L, Kandala N-B, Cappuccio FP (2009) Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ 339:b4567. https://doi.org/10.1136/bmj.b4567
doi: 10.1136/bmj.b4567
pubmed: 19934192
pmcid: 2782060
Swenne CA (2013) Baroreflex sensitivity: mechanisms and measurement. Neth Heart J 21:58–60. https://doi.org/10.1007/s12471-012-0346-y
doi: 10.1007/s12471-012-0346-y
pubmed: 23179611
Takeda R, Stickford ASL, Best SA, Yoo J-K, Hissen SL, Liu Y-L et al (2021) Impact of high-salt versus low-salt intake on the response of sympathetic baroreflex sensitivity to orthostasis in women with a history of normal pregnancy. Am J Physiol Regul Integr Comp Physiol 321:R260–R270. https://doi.org/10.1152/ajpregu.00069.2021
doi: 10.1152/ajpregu.00069.2021
pubmed: 34231375
Trožić I, Platzer D, Fazekas F, Bondarenko AI, Brix B, Rössler A et al (2020) Postural hemodynamic parameters in older persons have a seasonal dependency: a pilot study. Z Gerontol Geriatr 53:145–155. https://doi.org/10.1007/s00391-019-01525-3
doi: 10.1007/s00391-019-01525-3
pubmed: 30868225
Tzeng YC, Lucas S, Atkinson G, Willie C, Ainslie P. Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans. Journal of Applied Physiology (Bethesda, Md : 1985) 2010;108:1162–8. https://doi.org/10.1152/japplphysiol.01390.2009 .
Stewart JM (1985) Mechanisms of sympathetic regulation in orthostatic intolerance. J Appl Physiol 2012(113):1659–1668. https://doi.org/10.1152/japplphysiol.00266.2012
doi: 10.1152/japplphysiol.00266.2012
Stupin A, Drenjančević I, Šušnjara P, Debeljak Ž, Kolobarić N, Jukić I et al (2021) Is there association between altered adrenergic system activity and microvascular endothelial dysfunction induced by a 7-Day high salt intake in young healthy individuals. Nutrients 13:1731. https://doi.org/10.3390/nu13051731
doi: 10.3390/nu13051731
pubmed: 34065261
pmcid: 8161165
Wallin BG, Charkoudian N (2007) Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity. Muscle Nerve 36:595–614. https://doi.org/10.1002/mus.20831
doi: 10.1002/mus.20831
pubmed: 17623856
Witter T, Tzeng Y-C, O’Donnell T, Kusel J, Walker B, Berry M, et al. Inter-individual Relationships between Sympathetic Arterial Baroreflex Function and Cerebral Perfusion Control in Healthy Males. Frontiers in Neuroscience 2017;11.
Zhang R, Zuckerman JH, Iwasaki K, Wilson TE, Crandall CG, Levine BD (2002) Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation 106:1814–1820. https://doi.org/10.1161/01.cir.0000031798.07790.fe
doi: 10.1161/01.cir.0000031798.07790.fe
pubmed: 12356635
Zubac D, Ivančev V, Valić Z, Pišot R, Meulenberg CJW, Trozić I, et al. A Randomized Crossover Trial on the Acute Cardiovascular Demands During Flywheel Exercise. Front Physiol 2021;12:665462. https://doi.org/10.3389/fphys.2021.665462 .