Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent.


Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
27 01 2023
Historique:
pubmed: 5 1 2023
medline: 31 1 2023
entrez: 4 1 2023
Statut: ppublish

Résumé

Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate (OPCA) on a preclinical model of MS. First, OPCA was synthesized semisynthetically and characterized. Then, the mice with MOG

Identifiants

pubmed: 36598820
doi: 10.1021/acs.jnatprod.2c00798
pmc: PMC9887603
doi:

Substances chimiques

Cytokines 0
Anti-Inflammatory Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103-118

Références

J Proteomics. 2018 Sep 15;187:212-222
pubmed: 30086402
Neurology. 2019 Mar 5;92(10):e1029-e1040
pubmed: 30770430
Phytochemistry. 2012 May;77:10-5
pubmed: 22377690
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Neurobiol Dis. 2015 Apr;76:57-66
pubmed: 25680941
N Engl J Med. 2000 Sep 28;343(13):938-52
pubmed: 11006371
Front Cell Dev Biol. 2016 Jun 28;4:71
pubmed: 27551677
J Immunol. 2017 Jun 15;198(12):4553-4560
pubmed: 28583987
PLoS One. 2014 Apr 03;9(4):e93933
pubmed: 24699908
Nat Rev Dis Primers. 2018 Nov 8;4(1):43
pubmed: 30410033
J Nat Prod. 2006 Mar;69(3):482-7
pubmed: 16562861
Pharmacol Ther. 2018 May;185:34-49
pubmed: 29127024
J Immunol. 2015 Sep 15;195(6):2552-9
pubmed: 26238492
Methods Mol Biol. 2016;1304:81-90
pubmed: 25863784
Int J Mol Sci. 2021 Jan 30;22(3):
pubmed: 33573368
Ann Neurol. 2011 May;69(5):759-77
pubmed: 21520239
PLoS One. 2013 Sep 06;8(9):e74745
pubmed: 24040334
Altern Lab Anim. 2003 Mar-Apr;31(2):89-198
pubmed: 15612878
Mult Scler Relat Disord. 2018 Aug;24:11-19
pubmed: 29860197
Am J Med. 2020 Dec;133(12):1380-1390.e2
pubmed: 32682869
Sci Rep. 2018 Mar 23;8(1):5146
pubmed: 29572472
J Neuroinflammation. 2016 Nov 15;13(1):291
pubmed: 27846891
Dan Med Bull. 1999 Jun;46(3):183-96
pubmed: 10421978
Cells. 2020 Oct 14;9(10):
pubmed: 33066433
Nature. 1970 Aug 15;227(5259):680-5
pubmed: 5432063
Pharm Biol. 2020 Dec;58(1):925-931
pubmed: 32915696
Genome Res. 2011 May;21(5):688-96
pubmed: 21467265
Nat Rev Immunol. 2015 Sep 15;15(9):545-58
pubmed: 26250739
Cell Mol Immunol. 2005 Dec;2(6):439-48
pubmed: 16426494
J Clin Pathol. 2017 Oct;70(10):847-853
pubmed: 28360189
Front Cell Neurosci. 2020 Oct 27;14:599717
pubmed: 33192332
Br J Pharmacol. 2012 Jul;166(5):1708-23
pubmed: 22260389
J Neuroinflammation. 2020 Jan 14;17(1):21
pubmed: 31937331
Phytochem Rev. 2014 Dec;13(4):793-810
pubmed: 25395898
Autoimmun Rev. 2020 Oct;19(10):102647
pubmed: 32801039
Lancet. 2008 Oct 25;372(9648):1502-17
pubmed: 18970977
Front Immunol. 2020 Sep 18;11:2165
pubmed: 33072080
Expert Opin Pharmacother. 2017 Oct;18(15):1649-1660
pubmed: 28844164
Scand J Immunol. 2011 Jul;74(1):1-13
pubmed: 21338381
Front Cell Neurosci. 2019 Jul 31;13:355
pubmed: 31427930
N Engl J Med. 2006 Mar 2;354(9):942-55
pubmed: 16510748
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9671-9676
pubmed: 31004050
Semin Cell Dev Biol. 2021 Aug;116:3-9
pubmed: 33082115
Eur J Pharmacol. 2015 Jul 15;759:182-91
pubmed: 25823807
Neurology. 2014 Jul 15;83(3):278-86
pubmed: 24871874
Prog Lipid Res. 2009 May-Jul;48(3-4):206-38
pubmed: 19336244
Methods Mol Biol. 2016;1304:73-9
pubmed: 25208752
Clin Immunol. 2013 Dec;149(3):519-29
pubmed: 24239839
J Neuroimmunol. 2016 Sep 15;298:106-16
pubmed: 27609283
Annu Rev Neurosci. 2002;25:491-505
pubmed: 12052918
Mol Neurobiol. 2017 May;54(4):2950-2960
pubmed: 27023227
FEBS Lett. 2009 Dec 17;583(24):3966-73
pubmed: 19850042
Sci Rep. 2015 Jun 08;5:10775
pubmed: 26053859
Mult Scler. 2004 Oct;10(5):540-8
pubmed: 15471371
World J Clin Cases. 2020 May 26;8(10):1767-1792
pubmed: 32518769
J Neuroinflammation. 2020 Nov 27;17(1):363
pubmed: 33246492
Biol Pharm Bull. 2011;34(6):933-6
pubmed: 21628899
Int Rev Neurobiol. 2007;79:589-620
pubmed: 17531860
Acta Clin Croat. 2018 Jun;57(2):352-361
pubmed: 30431730
Front Immunol. 2020 Sep 29;11:572186
pubmed: 33117365
Lancet Neurol. 2020 Aug;19(8):678-688
pubmed: 32702337
Front Immunol. 2019 Jan 10;9:3116
pubmed: 30687321
Mult Scler. 2018 Jun;24(7):963-973
pubmed: 28554238
Med Chem. 2018;14(6):617-625
pubmed: 29473521
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Curr Opin Pharmacol. 2022 Apr;63:102194
pubmed: 35255453
Acta Neuropathol. 1997 Dec;94(6):590-8
pubmed: 9444361
J Transl Int Med. 2020 Sep 25;8(3):177-187
pubmed: 33062594
Mult Scler. 2020 Dec;26(14):1816-1821
pubmed: 33174475
Neuropathology. 2020 Feb;40(1):84-92
pubmed: 31709666
Trends Genet. 2017 Dec;33(12):960-970
pubmed: 28987266
Nat Immunol. 2001 Sep;2(9):762-4
pubmed: 11526378
Eye (Lond). 2017 Feb;31(2):232-240
pubmed: 27886183

Auteurs

Halil Senol (H)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.

Ozden Ozgun-Acar (O)

Seed Breeding & Genetics Application Research Center, Pamukkale University, 20070 Denizli, Turkey.

Aydan Dağ (A)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.

Ahmet Eken (A)

Department of Basic Medical Sciences, Faculty of Medicine, Medical Biology Erciyes University, 38039 Kayseri, Turkey.

Hüseyin Guner (H)

Department of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, University of Abdullah Gul 38080 Kayseri, Turkey.

Zaliha Gamze Aykut (ZG)

Laboratory Animals Facility, Bilkent University, 06800 Ankara, Turkey.

Gulacti Topcu (G)

Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey.

Alaattin Sen (A)

Department of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, University of Abdullah Gul 38080 Kayseri, Turkey.
Department of Biology, Faculty of Arts & Sciences, Pamukkale University, 20070 Kınıklı, Denizli, Turkey.

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Classifications MeSH