Structural brain plasticity and inflammation are independently related to changes in depressive symptoms six months after an index ECT course.

Depression ECT MRI imaging inflammation neuroimaging

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
05 Jan 2023
Historique:
entrez: 5 1 2023
pubmed: 6 1 2023
medline: 6 1 2023
Statut: aheadofprint

Résumé

Electroconvulsive therapy (ECT) is effective for treatment-resistant depression and leads to short-term structural brain changes and decreases in the inflammatory response. However, little is known about how brain structure and inflammation relate to the heterogeneity of treatment response in the months following an index ECT course. A naturalistic six-month study following an index ECT course included 20 subjects with treatment-resistant depression. Upon conclusion of the index ECT course and again after six months, structural magnetic resonance imaging scans and peripheral inflammation measures [interleukin-6 (IL-6), IL-8, tumor necrosis factor (TNF- Between the end of the index ECT course and the end of follow-up, we found four clusters of significant decreases in gray matter volume ( Six months after an index ECT course, multiple regions of decreased gray matter volume were observed in a naturalistic setting. The independent relations between brain volume and inflammation to depressive symptoms suggest novel explanations of the heterogeneity of longer-term ECT treatment response.

Sections du résumé

BACKGROUND BACKGROUND
Electroconvulsive therapy (ECT) is effective for treatment-resistant depression and leads to short-term structural brain changes and decreases in the inflammatory response. However, little is known about how brain structure and inflammation relate to the heterogeneity of treatment response in the months following an index ECT course.
METHODS METHODS
A naturalistic six-month study following an index ECT course included 20 subjects with treatment-resistant depression. Upon conclusion of the index ECT course and again after six months, structural magnetic resonance imaging scans and peripheral inflammation measures [interleukin-6 (IL-6), IL-8, tumor necrosis factor (TNF-
RESULTS RESULTS
Between the end of the index ECT course and the end of follow-up, we found four clusters of significant decreases in gray matter volume (
CONCLUSIONS CONCLUSIONS
Six months after an index ECT course, multiple regions of decreased gray matter volume were observed in a naturalistic setting. The independent relations between brain volume and inflammation to depressive symptoms suggest novel explanations of the heterogeneity of longer-term ECT treatment response.

Identifiants

DOI: 10.1017/S0033291722003555 PMID: 36600668
pubmed: 36600668
doi: 10.1017/S0033291722003555
pii: S0033291722003555
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-9

Subventions

Organisme : NIH HHS
ID : R01MH092301
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01CA119159
Pays : United States

Auteurs

John O Brooks (JO)

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
ORCID: 0000-0001-5420-7208

Jennifer L Kruse (JL)

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

Antoni Kubicki (A)

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, Geffen School of Medicine at the University of California, Los Angeles, CA, USA.

Gerhard Hellemann (G)

University of Alabama, Birmingham, AL, USA.

Randall T Espinoza (RT)

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

Michael R Irwin (MR)

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

Katherine L Narr (KL)

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, Geffen School of Medicine at the University of California, Los Angeles, CA, USA.

Classifications MeSH