Real-world effectiveness of sotrovimab and remdesivir for early treatment of high-risk hospitalized COVID-19 patients: A propensity score adjusted retrospective cohort study.


Journal

Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876

Informations de publication

Date de publication:
02 2023
Historique:
revised: 22 10 2022
received: 29 08 2022
accepted: 30 12 2022
pubmed: 6 1 2023
medline: 3 3 2023
entrez: 5 1 2023
Statut: ppublish

Résumé

Early treatment of high-risk COVID-19 patients may prevent disease progression. However, there are limited data to support treatment of hospitalized or fully vaccinated patients with mild-to-moderate disease. In this retrospective cohort study, we studied the effect of early use of sotrovimab and remdesivir in high-risk hospitalized COVID-19 patients. We included PCR-confirmed COVID-19 patients admitted to the National Centre for Infectious Diseases who presented within the first 5 days of illness, and who were not requiring oxygen or ICU care at presentation. Sotrovimab- and remdesivir-treated groups were compared with control (no early treatment). A multiple propensity-score adjusted multivariable regression analysis was conducted with a composite primary endpoint of in-hospital deterioration (oxygen requirement, ICU admission, or mortality). Of 1118 patients, 841 were in the control group, 106 in the sotrovimab group and 169 in the remdesivir group. The median age was 63 years (IQR 46-74 years) and 505 (45.2%) were female. In unvaccinated patients, both remdesivir and sotrovimab treatment were protective (adjusted odds ratio [aOR] 0.19, 95% CI 0.064-0.60 and 0.18 [95% CI 0.066-0.47]), respectively. Contrarily, among the vaccinated patients there was no significant treatment effect with early remdesivir treatment (aOR 2.51, 95% CI 0.83-7.57, p = 0.10). Remdesivir and sotrovimab treatment, given early in the disease course to unvaccinated high-risk patients, was effective in reducing the risk of in-hospital deterioration and severe disease. This effect was not seen in fully vaccinated patients, which may be due to a small sample size or residual confounding.

Identifiants

pubmed: 36602046
doi: 10.1002/jmv.28460
doi:

Substances chimiques

remdesivir 3QKI37EEHE
sotrovimab 1MTK0BPN8V
Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e28460

Informations de copyright

© 2023 Wiley Periodicals LLC.

Références

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Auteurs

Lin Pin Koh (LP)

National Centre for Infectious Diseases, Singapore, Singapore.
Anglo-Chinese School (Independent), Singapore, Singapore.

Siang Li Chua (SL)

National Centre for Infectious Diseases, Singapore, Singapore.

Shawn Vasoo (S)

National Centre for Infectious Diseases, Singapore, Singapore.
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Matthias Paul Han Sim Toh (MPHS)

National Centre for Infectious Diseases, Singapore, Singapore.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Jeremy Nicholas Cutter (JN)

National Centre for Infectious Diseases, Singapore, Singapore.

Puay Hoon Nah (PH)

National Centre for Infectious Diseases, Singapore, Singapore.

Yee-Sin Leo (YS)

National Centre for Infectious Diseases, Singapore, Singapore.
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Jun Xin Tay (JX)

National Centre for Infectious Diseases, Singapore, Singapore.

Barnaby Edward Young (BE)

National Centre for Infectious Diseases, Singapore, Singapore.
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

David C Lye (DC)

National Centre for Infectious Diseases, Singapore, Singapore.
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Sean W X Ong (SWX)

National Centre for Infectious Diseases, Singapore, Singapore.
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.

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