Crystal Structure Analysis of Sarcoplasmic-Calcium-Binding Protein: An Allergen in

Animals Allergens / chemistry Amino Acid Sequence Calcium-Binding Proteins / chemistry Immunoglobulin E Brachyura / genetics Epitopes / chemistry
Scylla paramamosain allergen calcium-binding capacity crystal structure sarcoplasmic-calcium-binding protein

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
18 Jan 2023
Historique:
pubmed: 6 1 2023
medline: 20 1 2023
entrez: 5 1 2023
Statut: ppublish

Résumé

The structure of allergenic proteins provides important information about the binding of allergens to antibodies. In this study, the crystal structure of Scy p 4 with a resolution of 1.60 Å was obtained by X-ray diffraction. Epitope mapping of Scy p 4 revealed that linear epitopes are located on the surface of Scy p 4. Also, conformational epitopes are mostly located in the structural conservative region. Further structural comparison, surface electrostatic potential, and hydrogen bond force analysis showed that mutation of Asp

Identifiants

DOI: 10.1021/acs.jafc.2c07267 PMID: 36602420
pubmed: 36602420
doi: 10.1021/acs.jafc.2c07267
doi:

Substances chimiques

Allergens 0
Calcium-Binding Proteins 0
Immunoglobulin E 37341-29-0
Epitopes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1214-1223

Auteurs

Yiyu Chen (Y)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.
College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.

Tengchuan Jin (T)

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui 230026, China.
ORCID: 0000-0002-1395-188X

Mengsi Li (M)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.

Xiao Yun (X)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.

Fei Huan (F)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.

Qingmei Liu (Q)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.

Mengjun Hu (M)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.

Xiaofeng Wei (X)

College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China.
ORCID: 0000-0002-1341-8938

Peiyi Zheng (P)

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui 230026, China.

Guangming Liu (G)

College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China.
ORCID: 0000-0002-8689-0504

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Crystal Structure Analysis of...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Crystal Structure Analysis of...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Crystal Structure Analysis of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Crystal Structure Analysis of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline E › Crystal Structure Analysis of...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Crustacea › Decapoda (crustacea) › Brachyura › Crystal Structure Analysis of...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Crystal Structure Analysis of...