Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.

Animals Mice Atrophy / metabolism Disease Models, Animal Growth Hormone-Releasing Hormone / agonists Motor Neurons / metabolism Muscular Atrophy, Spinal / drug therapy Spinal Cord / metabolism Survival of Motor Neuron 1 Protein / genetics
GHRH agonists alpha motor neurons neuroinflammation neuromuscular junction spinal muscular atrophy

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
10 01 2023
Historique:
entrez: 5 1 2023
pubmed: 6 1 2023
medline: 10 1 2023
Statut: ppublish

Résumé

Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene (

Identifiants

DOI: 10.1073/pnas.2216814120 PMID: 36603028 PMC: PMC9926281
pubmed: 36603028
doi: 10.1073/pnas.2216814120
pmc: PMC9926281
doi:

Substances chimiques

Growth Hormone-Releasing Hormone 9034-39-3
Survival of Motor Neuron 1 Protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2216814120

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Auteurs

Marina Boido (M)

Department of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.
ORCID: 0000-0003-1211-1552

Iacopo Gesmundo (I)

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0003-4901-4764

Anna Caretto (A)

Department of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.

Francesca Pedrolli (F)

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0001-9404-7691

Roberta Schellino (R)

Department of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.

Sheila Leone (S)

Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.
ORCID: 0000-0003-1291-550X

Renzhi Cai (R)

Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.
South Florida VA Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125.

Wei Sha (W)

Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.

Ezio Ghigo (E)

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Andrew V Schally (AV)

Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.
South Florida VA Foundation for Research and Education, Veterans Affairs Medical Center, Miami, FL 33125.
Divisions of Medical/Oncology and Endocrinology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136.
Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136.
Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136.
ORCID: 0000-0003-1273-6747

Alessandro Vercelli (A)

Department of Neuroscience "Rita Levi Montalcini", Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Turin, Italy.
ORCID: 0000-0002-5909-2128

Riccarda Granata (R)

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0003-4164-7313

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Hormone de libération de l'hormone de croissance › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Maladies du motoneurone › Amyotrophie spinale › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Agonist of growth hormone-releasing hormone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines du complexe SMN › Protéine-1 de survie du motoneurone › Agonist of growth hormone-releasing hormone...