Detection of Early Esophageal Neoplastic Barrett Lesions with Quantified Fluorescence Molecular Endoscopy Using Cetuximab-800CW.

Humans Cetuximab Fluorescence Esophageal Neoplasms / diagnostic imaging Barrett Esophagus / diagnostic imaging Endoscopy Adenocarcinoma / diagnostic imaging ErbB Receptors / metabolism
Barrett esophagus cetuximab epidermal growth factor receptor esophageal adenocarcinoma fluorescence molecular imaging

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
05 2023
Historique:
received: 13 07 2022
revised: 06 12 2022
medline: 1 5 2023
pubmed: 6 1 2023
entrez: 5 1 2023
Statut: ppublish

Résumé

Esophageal adenocarcinoma causes 6% of cancer-related deaths worldwide. Near-infrared fluorescence molecular endoscopy (NIR-FME) uses a tracer that targets overexpressed proteins. In this study, we aimed to investigate the feasibility of an epidermal growth factor receptor (EGFR)-targeted tracer, cetuximab-800CW, to improve detection of early-stage esophageal adenocarcinoma.

Identifiants

DOI: 10.2967/jnumed.122.264656 PMID: 36604181
pubmed: 36604181
pii: jnumed.122.264656
doi: 10.2967/jnumed.122.264656
doi:

Substances chimiques

Cetuximab PQX0D8J21J
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

803-808

Informations de copyright

© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Ruben Y Gabriëls (RY)

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Lisanne E van Heijst (LE)

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Wouter T R Hooghiemstra (WTR)

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Anne M van der Waaij (AM)

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Gursah Kats-Ugurlu (G)

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Arend Karrenbeld (A)

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Dominic J Robinson (DJ)

Otolaryngology, Center for Optic Diagnostics and Therapy, Erasmus University Medical Center, Rotterdam, The Netherlands.

Anna Tenditnaya (A)

Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany; and.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.

Vasilis Ntziachristos (V)

Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany; and.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.

Dimitris Gorpas (D)

Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany; and.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.

Wouter B Nagengast (WB)

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; w.b.nagengast@umcg.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Cétuximab › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Phénomènes physiques › Phénomènes optiques › Fluorescence › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Tumeurs de l'oesophage › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'oesophage › Oesophage de Barrett › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Procédures de chirurgie opératoire › Interventions chirurgicales mini-invasives › Endoscopie › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Detection of Early Esophageal Neoplastic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Detection of Early Esophageal Neoplastic...