Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 01 2023
05 01 2023
Historique:
received:
27
07
2021
accepted:
08
12
2022
entrez:
5
1
2023
pubmed:
6
1
2023
medline:
10
1
2023
Statut:
epublish
Résumé
Fibro-adipogenic progenitors (FAPs) play a crucial role in skeletal muscle regeneration, as they generate a favorable niche that allows satellite cells to perform efficient muscle regeneration. After muscle injury, FAP content increases rapidly within the injured muscle, the origin of which has been attributed to their proliferation within the muscle itself. However, recent single-cell RNAseq approaches have revealed phenotype and functional heterogeneity in FAPs, raising the question of how this differentiation of regenerative subtypes occurs. Here we report that FAP-like cells residing in subcutaneous adipose tissue (ScAT), the adipose stromal cells (ASCs), are rapidly released from ScAT in response to muscle injury. Additionally, we find that released ASCs infiltrate the damaged muscle, via a platelet-dependent mechanism and thus contribute to the FAP heterogeneity. Moreover, we show that either blocking ASCs infiltration or removing ASCs tissue source impair muscle regeneration. Collectively, our data reveal that ScAT is an unsuspected physiological reservoir of regenerative cells that support skeletal muscle regeneration, underlining a beneficial relationship between muscle and fat.
Identifiants
pubmed: 36604419
doi: 10.1038/s41467-022-35524-7
pii: 10.1038/s41467-022-35524-7
pmc: PMC9816314
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
80Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s).
Références
Nat Cell Biol. 2010 Feb;12(2):153-63
pubmed: 20081841
Ann Anat. 2015 Nov;202:18-27
pubmed: 26340019
Front Immunol. 2012 Sep 12;3:283
pubmed: 22988448
J Biophys Biochem Cytol. 1961 Feb;9:493-5
pubmed: 13768451
iScience. 2020 Apr 24;23(4):100993
pubmed: 32248062
Stem Cell Res. 2016 Jul;17(1):161-9
pubmed: 27376715
J Cell Sci. 2019 Oct 9;132(19):
pubmed: 31434718
Nat Med. 2012 Aug;18(8):1262-70
pubmed: 22842476
Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9
pubmed: 31809738
BMC Dev Biol. 2009 Sep 09;9:49
pubmed: 19740427
J Bone Miner Res. 2012 May;27(5):1004-17
pubmed: 22307978
Adv Mater. 2009 Sep 4;21(32-33):3255-68
pubmed: 20882496
Front Immunol. 2020 May 19;11:951
pubmed: 32508832
Cell Tissue Res. 2016 Jun;364(3):647-660
pubmed: 26742767
Nat Commun. 2021 Feb 15;12(1):1041
pubmed: 33589633
Front Physiol. 2021 Apr 20;12:673404
pubmed: 33959042
Front Immunol. 2019 Jun 05;10:1194
pubmed: 31231371
J Clin Invest. 2006 Dec;116(12):3220-8
pubmed: 17143331
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):143-8
pubmed: 21173238
J Cell Mol Med. 2020 Sep;24(17):10140-10150
pubmed: 32681815
Cell Death Dis. 2021 Jan 25;12(1):122
pubmed: 33495447
Stem Cells. 2011 May;29(5):749-54
pubmed: 21433220
Adipocyte. 2016 Jan 06;5(3):312-7
pubmed: 27617752
FEBS J. 2013 Sep;280(17):4100-8
pubmed: 23763717
Development. 2013 Jul;140(14):2879-91
pubmed: 23739133
Trends Immunol. 2020 Jun;41(6):481-492
pubmed: 32362490
Stem Cell Res. 2018 Oct;32:8-16
pubmed: 30149291
Stem Cells. 2018 Jul;36(7):1062-1074
pubmed: 29488279
J Cell Sci. 2019 Feb 25;132(5):
pubmed: 30745334
Nat Cell Biol. 2010 Feb;12(2):143-52
pubmed: 20081842
Stem Cells. 2015 Jan;33(1):265-77
pubmed: 25263183
Skelet Muscle. 2021 Jul 1;11(1):16
pubmed: 34210364
Int J Obes (Lond). 2016 Mar;40(3):497-506
pubmed: 26395744
Mol Metab. 2018 Mar;9:187-191
pubmed: 29398617
Dev Cell. 2018 Jul 16;46(2):135-143
pubmed: 30016618
Science. 2008 Oct 24;322(5901):583-6
pubmed: 18801968
Cell. 2013 Apr 11;153(2):376-88
pubmed: 23582327
FASEB J. 2014 Sep;28(9):4123-32
pubmed: 24948596
Front Physiol. 2019 Aug 21;10:1074
pubmed: 31496956
Physiol Rev. 2004 Jan;84(1):209-38
pubmed: 14715915
Development. 2011 Sep;138(17):3625-37
pubmed: 21828091
Front Immunol. 2020 May 12;11:915
pubmed: 32477368
Cell Rep. 2019 Apr 9;27(2):323-333.e5
pubmed: 30970240
Cell Signal. 2021 Aug;84:110036
pubmed: 33971280
JCI Insight. 2020 Mar 26;5(6):
pubmed: 32106110
Nat Med. 2015 Jul;21(7):786-94
pubmed: 26053624
Am J Pathol. 2017 Aug;187(8):1814-1827
pubmed: 28618254
J Clin Invest. 2019 Oct 1;129(10):4022-4031
pubmed: 31573549
Cell Death Differ. 2020 Oct;27(10):2921-2941
pubmed: 32382110
Cell Death Dis. 2015 Apr 23;6:e1733
pubmed: 25906156
Front Cell Dev Biol. 2021 Jan 08;8:598520
pubmed: 33490065
Bioengineering (Basel). 2020 Jul 20;7(3):
pubmed: 32698352
FEBS J. 2022 Nov;289(21):6484-6517
pubmed: 34143565
Geroscience. 2017 Apr;39(2):187-198
pubmed: 28409332
J Appl Physiol (1985). 2001 Aug;91(2):534-51
pubmed: 11457764
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 33170806
Cold Spring Harb Perspect Med. 2018 Aug 1;8(8):
pubmed: 28507197
Cell Stem Cell. 2009 Mar 6;4(3):206-16
pubmed: 19265660
Front Physiol. 2020 May 19;11:495
pubmed: 32508678
Sci Rep. 2019 Dec 27;9(1):20120
pubmed: 31882966
Cell. 2008 Oct 17;135(2):240-9
pubmed: 18835024
Cell Transplant. 2012;21(7):1463-75
pubmed: 22525351
Cells. 2021 Nov 03;10(11):
pubmed: 34831213
PLoS One. 2016 Jan 25;11(1):e0147198
pubmed: 26807982
J Biol Chem. 2007 Sep 7;282(36):25993-6001
pubmed: 17616532
Cell Stem Cell. 2018 Jun 01;22(6):824-833
pubmed: 29859173
Nat Commun. 2018 Sep 10;9(1):3670
pubmed: 30202063
Stem Cells. 2013 Jul;31(7):1309-20
pubmed: 23533182
Development. 2011 Jan;138(2):371-84
pubmed: 21177349
J Cell Physiol. 2005 Oct;205(1):114-22
pubmed: 15880450
Development. 2011 Sep;138(17):3647-56
pubmed: 21828093
Int J Obes (Lond). 2014 Sep;38(9):1255-62
pubmed: 24357852