Explaining the unexpected COVID-19 trends and potential impact across Africa.
COVID-19
Immunobiography
Inflamm-aging
Inflammation
Long COVID
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2021
2021
Historique:
accepted:
16
09
2022
entrez:
9
1
2023
pubmed:
22
11
2021
medline:
11
1
2023
Statut:
epublish
Résumé
Official COVID-19 case counts and mortality rates across Africa are lower than had been anticipated. Research reports, however, indicate far higher exposure rates than the official counts in some countries. Particularly in Western and Central Africa, where mortality rates are disproportionately lower than the rest of the continent, this occurrence may be due to immune response adaptations resulting from (1) frequent exposure to certain pro-inflammatory pathogens, and (2) a prevalence of low-grade inflammation coupled with peculiar modifications to the immune response based on one's immunobiography. We suggest that the two factors lead to a situation where post infection, there is a rapid ramp-up of innate immune responses, enough to induce effective defense and protection against plethora pathogens. Alongside current efforts at procuring and distributing vaccines, we draw attention to the need for work towards appreciating the impact of the apparently widespread, asymptomatic SARS-CoV-2 infections on Africa's populations
Identifiants
pubmed: 36605410
doi: 10.12688/f1000research.74363.2
pmc: PMC9763772.2
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1177Subventions
Organisme : Medical Research Council
ID : MR/P028071/1
Pays : United Kingdom
Informations de copyright
Copyright: © 2022 Oduro-Mensah D et al.
Déclaration de conflit d'intérêts
No competing interests were disclosed.
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