Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy.
Cortical thickness
Essential tremor
Mean curvature
Morphometry
Radiosurgery
Structural covariance analysis
Surface area
Thalamotomy
Ventro-intermediate nucleus
Journal
Network neuroscience (Cambridge, Mass.)
ISSN: 2472-1751
Titre abrégé: Netw Neurosci
Pays: United States
ID NLM: 101719149
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
16
02
2022
accepted:
02
05
2022
entrez:
6
1
2023
pubmed:
7
1
2023
medline:
7
1
2023
Statut:
epublish
Résumé
Essential tremor (ET) is the most common movement disorder. Its neural underpinnings remain unclear. Here, we quantified structural covariance between cortical thickness (CT), surface area (SA), and mean curvature (MC) estimates in patients with ET before and 1 year after ventro-intermediate nucleus stereotactic radiosurgical thalamotomy, and contrasted the observed patterns with those from matched healthy controls. For SA, complex rearrangements within a network of motion-related brain areas characterized patients with ET. This was complemented by MC alterations revolving around the left middle temporal cortex and the disappearance of positive-valued covariance across both modalities in the right fusiform gyrus. Recovery following thalamotomy involved MC readjustments in frontal brain centers, the amygdala, and the insula, capturing nonmotor characteristics of the disease. The appearance of negative-valued CT covariance between the left parahippocampal gyrus and hippocampus was another recovery mechanism involving high-level visual areas. This was complemented by the appearance of negative-valued CT/MC covariance, and positive-valued SA/MC covariance, in the right inferior temporal cortex and bilateral fusiform gyrus. Our results demonstrate that different morphometric properties provide complementary information to understand ET, and that their statistical cross-dependences are also valuable. They pinpoint several anatomical features of the disease and highlight routes of recovery following thalamotomy.
Identifiants
pubmed: 36605417
doi: 10.1162/netn_a_00253
pii: netn_a_00253
pmc: PMC9810368
doi:
Types de publication
Journal Article
Langues
eng
Pagination
850-869Informations de copyright
© 2022 Massachusetts Institute of Technology.
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