Colonic Mucosal Infiltration of IgG4 Plasma Cells and Ulcerative Colitis: Determinant of Presence, Activity, Extension, and Duration of Disease.
Disease activity
Duration of disease
Extension of disease
IgG4 plasma cells
Primary sclerosing cholangitis
Ulcerative colitis
Journal
Middle East journal of digestive diseases
ISSN: 2008-5230
Titre abrégé: Middle East J Dig Dis
Pays: Iran
ID NLM: 101535395
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
21
01
2021
accepted:
11
06
2021
entrez:
6
1
2023
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
ppublish
Résumé
BACKGROUND Infiltration of IgG4 positive plasma cells has been detected in the colonic mucosa of patients with ulcerative colitis (UC). The aim of the study was to investigate the association between colonic mucosal infiltration of IgG4 plasma cells and the presence, activity, extension, and duration of UC. METHODS In this case-control study (2009-2014), 102 subjects (84 with UC/18 controls) were enrolled. Clinical records and rectosigmoid biopsies of UC patients were selected, and biopsies were stained with IgG4 monoclonal antibodies. IgG4 positive plasma cells were counted by a single pathologist. RESULTS Amongst 84 patients with UC, 73.8% had UC without primary sclerosing cholangitis (PSC), and 26.2% had UC with PSC. IgG4 plasma cells were seen in 35 (41.7%) patients with UC and 0% of controls (
Identifiants
pubmed: 36606008
doi: 10.34172/mejdd.2021.237
pmc: PMC9489443
doi:
Types de publication
Journal Article
Langues
eng
Pagination
287-293Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST The authors declare no conflict of interest related to this work.
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