Epidemiological and Clinical Factors Associated with Spontaneous Clearance of Hepatitis C Virus.
Diabetes
Diagnostic circumstances
Hepatitis B co-infection
Hepatitis C virus
Spontaneous clearance
Journal
Middle East journal of digestive diseases
ISSN: 2008-5230
Titre abrégé: Middle East J Dig Dis
Pays: Iran
ID NLM: 101535395
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
19
08
2020
accepted:
28
01
2021
entrez:
6
1
2023
pubmed:
1
10
2021
medline:
1
10
2021
Statut:
ppublish
Résumé
BACKGROUND The risk of chronicity is high after acute hepatitis C. The infection remains limited and spontaneously resolves in an average of 30% of subjects. Such subjects are considered recovered and do not require any medical care. This study aims to evaluate the epidemiological and clinical factors associated with spontaneous viral clearance. METHODS We conducted a descriptive retrospective study on patients' files managed for a positive hepatitis C serology who benefited from the research of serum viral RNA by molecular biology. RESULTS The study collected 429 usable files. The mean age of the patients was 50.21 years, and the sex ratio was 0.98. Spontaneous viral clearance was estimated at 17.2%. The univariate analysis showed that clearance was significantly greater in subjects under the age of 50 years, patients without type 2 diabetes, patients co-infected with hepatitis B virus, patients with transfusion, and those diagnosed fortuitously. Multivariate analysis confirmed the relationship between diabetes and the circumstances of the diagnosis. The relationship in the case of hepatitis B co-infection was very close to the statistical significance level (
Identifiants
pubmed: 36606021
doi: 10.34172/mejdd.2021.241
pmc: PMC9489441
doi:
Types de publication
Journal Article
Langues
eng
Pagination
321-327Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST The authors declare no conflict of interest related to this work.
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